Multiple meningiomas (case report)

Meningiomas, extracerebral tumors of the dura mater, are the most common tumors of the nervous system (i.e., 15% of all the intracranial neoplasms and 30–35% of central nervous system tumors). Multiple meningiomas are 1–10% of all the meningioma cases. This disease is more common in elderly patients (average age of the first meningioma detection is about 55 years), and it represents a major issue for diagnosis and management selection. Both sporadic meningiomatosis cases and a family history of autosomal dominant meningiomatosis are reported. A number of meningiomas per a patient can vary from 2–5 to ≥50; they can be located supratentorially, infratentorially and throughout the spinal canal. Multiple meningiomas have a negative effect on the disease prognosis. According to available data, each newly detected lesion leads to a progressive decrease in a survival rate. The paper presents a brief literature review on diagnosis and treatment of multiple meningiomas, as well as clinical observation of a young patient with sequentially detected multiple meningiomas (12 lesions) localized intracranially and throughout the spinal canal and mutation in the SMARCE1 gene. KEYWORDS: multiple meningiomas, meningiomatosis, sporadic meningiomatosis, diagnosis, disease management. FOR CITATION: Starikova N.L., Bystrova O.V., Kornilovich A.A. Multiple meningiomas (case report). Russian Medical Inquiry. 2024;8(10):582– 586 (in Russ.). DOI: 10.32364/2587-6821-2024-8-10-6