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Alpha-1-Antitrypsin Deficiency and Liver Disease
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Alpha-1-antitrypsin deficiency is a common autosomal recessive disorder associated with premature development of emphysema, liver cirrhosis and hepatocellular carcinoma. This article reviews the existing literature on alpha-1-antitrypsin deficiency, with an emphasis on recent developments. A description of the protein, gene structure and function of alpha-1-antitrypsin as well as clinical aspects are presented. Treatment issues are addressed and a framework for the diagnostic workup and management of patients with alpha-1-antitrypsin deficiency and chronic liver disease is provided.
Title: Alpha-1-Antitrypsin Deficiency and Liver Disease
Description:
Alpha-1-antitrypsin deficiency is a common autosomal recessive disorder associated with premature development of emphysema, liver cirrhosis and hepatocellular carcinoma.
This article reviews the existing literature on alpha-1-antitrypsin deficiency, with an emphasis on recent developments.
A description of the protein, gene structure and function of alpha-1-antitrypsin as well as clinical aspects are presented.
Treatment issues are addressed and a framework for the diagnostic workup and management of patients with alpha-1-antitrypsin deficiency and chronic liver disease is provided.
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