Dupuytren's Disease: A Comprehensive Review of Pathogenesis, Clinical Manifestations, and Therapeutic Strategies

Dupuytren's disease, a fibroproliferative disorder of the hand, remains a challenging pathology with significant impact on hand function and quality of life. This article provides a thorough examination of the intricate pathogenesis underlying Dupuytren's disease, delving into the molecular and cellular mechanisms driving abnormal collagen deposition in the palmar fascia. A detailed analysis of the clinical manifestations, from early nodules to advanced contractures, sheds light on the progressive nature of this condition. Furthermore, we explore the intricate interplay between genetic predisposition, environmental factors, and Dupuytren's disease, unraveling the multifaceted etiological landscape. This review synthesizes current diagnostic modalities, emphasizing the importance of advanced imaging techniques and biomarkers for accurate and timely assessment. Additionally, we discuss both conservative and surgical interventions, highlighting emerging therapeutic strategies such as enzyme-based therapies, gene therapies, and novel surgical approaches. The article aims to provide clinicians, researchers, and healthcare professionals with a comprehensive understanding of Dupuytren's disease, fostering a nuanced approach to diagnosis and management.