The relationship of Fetuin-A, Omentin-1 and Chemerin with clinical classification in Heart Failure

BACKGROUND: Heart failure (HF) is a clinical syndrome in which the heart cannot pump enough blood for the needs of the human body in terms of life functions. Some biochemical diagnostic tests as well as echocardiography play a role in the early diagnosis of this syndrome. The complex pathophysiology of HF suggests that many other markers may be useful in diagnosis and follow-up. AIM: After many recent studies, it has been suggested that adipokines fetuin-A, omentin-1 and chemerin may be suitable biomarkers for the diagnosis of HF. Our main aim in this study is to determine the relationship between fetuin-A, omentin-1 and chemerin levels with HF clinical classification. METHOD: The patients admitted to the cardiology service with symptomatic HF with heart failure with preserved ejection fraction (HF-pEF, n=62), heart failure with reduced EF (HF-rEF, n=61) and heart failure with mid-range EF (HF-mrEF, n=63) were included in the study. A total of 246 participants were evaluated by taking the control group (n=60) for comparison. The main characteristics of all groups were recorded and serum levels of fetuin-A, omentin-1 and chemerin were evaluated. RESULTS: When compared with the control group, there was a significant difference for fetuin-A with the HF-rEF group [452.3 (441.4-528.9); 555.3 (453.7-615.6) p<0.001, respectively]. When evaluating for omentin-1, there was a significant difference between the control group and HF-rEF [19.3 (16.9-22.7); 22.9 (16.8-29.7) p<0.001, respectively]. However, there was no significant difference for chemerin between the HF groups and the control group. Significant cut-off value for fetuin-A was found to be 485 in ROC analysis (AUC: 0.74 sens: 0.72 (95% CI: 0.57-0.82), spec: 0.69 (95% CI: 0.59-0.83), p<0.001). CONCLUSION: Serum fetuin-A levels were found to be increased in HF, especially in the HF-rEF group and it can be used in the diagnosis of this patient group.