COMPARE THE CLINICAL EFFICACY OF AZITHROMYCIN WITH CIPROFLOXACIN IN TREATMENT OF TYPHOID FEVER IN CHILDREN

Objective: To compare the clinical efficacy of Azithromycin with ciprofloxacin in treatment of typhoid fever in children. Setting: The study was conducted in Paediatric department Lahore General Hospital/PGMI Lahore from 11-12-2012 to 11-02-2012 Methodology: After permission from hospital ethical committee and informed written consent taken from attendants of patients of inclusion criteria, data was collected on data collection Performa. Patients fulfilling the criteria were admitted in Paediatric department, Lahore General Hospital. Patients were divided by lottery method into two groups A and B. Group A was given ciprofloxacin 15mg/kg/dose BD orally for 7 days. Group B was given azithromycin 10mg/kg/dose OD orally for 7 days. Both groups were kept under close observation for 7 days. Monitoring of patient during stay was done by researcher. The cost of medicine was beard by hospital. Results: In our study, 65%(n=65) in Group-A and 52%(n=52) in Group-B were between 3-8 years of age while 35%(n=35) in Group-A and 48%(n=48) in Group-B were between 9-14 years of age, mean+sd was calculated as 7.07+3.25 and 8.27+3.03 years respectively, 48%(n=48) in Group-A and 55%(n=55) in Group-B were male while 52%(n=52) in Group-A and 45%(n=45) in Group-B were females. Comparison of efficacy of oral azithromycin versus Ciprofloxacin in children with enteric fever shows that 72%(n=72) in Group-A and 85%(n=85) in Group-B were treated effectively, p value was calculated as 0.02 showing a significant difference. Conclusion: We concluded that the clinical efficacy of Azithromycin is significantly higher when compared with ciprofloxacin in treatment of typhoid fever in children.