Factors related to cerebral venous sinus thrombosis: A cross-sectional study

Abstract Objective: To study the factors related to cerebral venous sinus thrombosis (CVST) and to provide experience in single-center diagnosis and treatment of severe CVST, the relationship between high altitude and CVST and its possible mechanism was analyzed. Methods: The clinical data of 33 CVST patients treated in the General Hospital of Xinjiang Military Command from March 2018 to January 2022 were collected. During the same period, 882 non-CVST patients who were admitted to the hospital for treatment were selected as the control group, and the clinical data of both groups were collected. A cross-sectional study was used to analyze the factors related to CVST. Results: Multivariate logistic regression analysis showed that age, high altitude, systemic disease and surgical status were statistically significant (P < 0.05). Conclusion: Age, high altitude, systemic disease and surgical status may be influencing factors of the occurrence of CVST. The pathogenesis of CVST caused by high altitude is complex; the specific mechanism is unknown but may be mainly related to hypoxia, dehydration, polycythemia, vascular endothelial cell injury, blood flow status and coagulation function changes. In the future, these results may be further verified by establishing an animal model of CVST under altitude hypoxia conditions.