Abstract P4-13-15: A retrospective head-to-head comparison between TiLoop Bra/TiMesh and seragyn in 320 cases of reconstructive breast surgery

Abstract Background: As an alternative option to ADMs (acellular dermal matrices) synthetic meshes are a cheaper and equally effective option in implanted breast reconstruction. However, clinical data concerning these synthetic meshes is limited. Also, direct comparisons between titanium-coated polypropylene mesh (TiLoop Bra/TiMesh) and partially absorbable polypropylene mesh (Seragyn) have not yet been reported. Therefore, this work will report clinical complication rate data on 320 cases of synthetic meshes TiLoop Bra/TiMesh and Seragyn. Methods: This analysis represents a retrospective single surgeon multi-center study of 320 cases over 14 years (2003 until 2016) using either TiLoop Bra/TiMesh (n=192) or Seragyn (n=128) in breast reconstruction. Patient recruitment was consecutive. 124 cases of the TiLoop Bra /TiMesh cohort and 74 cases in the Seragyn cohort were oncological interventions. Results were correlated with ADM based reconstructions (Epiflex and SurgiMend) performed by the same surgeon. Results: Major complication rates (i.e. revision surgery) occurred in 3.9 % (Seragyn) and 8.3 % (TiLoop Bra/TiMesh) of all cases. (not statistically significant). Minor complications (i.e. seroma requiring aspiration, infection requiring antibiotics, red breast syndrome/rash (RBS) and wound dehiscence occurred in 18 % (Seragyn) and 8.9 % (TiLoop Bra/TiMesh). Overall minor complication rates did also not differ statistically significant. However, subgroup analysis showed RBS to occur more often in the Seragyn group (3.9 % Seragyn vs. 0.5 % TiLoop Bra/TiMesh, p<0.05). A significant difference between SurgiMend and Epiflex compared to the synthetic meshes could also not been shown. Conclusion: This retrospective analysis shows that titanium-coated polypropylene meshes like TiLoop Bra/TiMesh and partially absorbable meshes like Seragyn do not differ significantly in complication rates. Compared to the exponentially more expensive ADM alternatives complication rates did also not differ significantly. Synthetic meshes seem to be a cheaper and equally effective option. Citation Format: Eichler C, Schulz C, Brunnert K, Mathias W. A retrospective head-to-head comparison between TiLoop Bra/TiMesh and seragyn in 320 cases of reconstructive breast surgery [abstract]. In: Proceedings of the 2017 San Antonio Breast Cancer Symposium; 2017 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2018;78(4 Suppl):Abstract nr P4-13-15.