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Brain Metastases
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In the past, detection of brain metastases signaled the conclusion of aggressive systemic treatment and shifted the focus of care toward palliation. The median survival for patients with single brain metastasis without brain-directed treatment is about a month. Whole brain radiation therapy was the traditional palliative treatment utilized, offering an additional 2 to 5 months. More recently, in addition to whole brain irradiation, the roles of surgery, stereotactic radiosurgery, chemotherapy, and targeted therapies in the definitive management of brain metastases have been investigated in numerous studies. In selected patients, the use of aggressive local therapies can be associated with long survival and good quality of life. This chapter discusses the current state of the art therapeutic options for brain metastases.
Title: Brain Metastases
Description:
In the past, detection of brain metastases signaled the conclusion of aggressive systemic treatment and shifted the focus of care toward palliation.
The median survival for patients with single brain metastasis without brain-directed treatment is about a month.
Whole brain radiation therapy was the traditional palliative treatment utilized, offering an additional 2 to 5 months.
More recently, in addition to whole brain irradiation, the roles of surgery, stereotactic radiosurgery, chemotherapy, and targeted therapies in the definitive management of brain metastases have been investigated in numerous studies.
In selected patients, the use of aggressive local therapies can be associated with long survival and good quality of life.
This chapter discusses the current state of the art therapeutic options for brain metastases.
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