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Neuronal globus pallidus activity in patients with generalised dystonia
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AbstractWe studied 516 globus pallidus neurons in dystonic patients. The firing rate was analysed. We classified the burst activity into tonic, burst, and pause patterns. Mean ± SD firing rates and tonicity score for internal globus pallidus (GPi) and external globus pallidus (GPe) were 54.6 ± 28.6; 58.01 ± 39.1 and 1.18 ± 0.55; 0.95 ± 0.43, respectively. Differences in percentage appearance of tonic, burst, or paused neurons were not statistically significant for GPi versus GPe. GPi firing features in dystonic patients were closely similar to those of GPe. This could suggest that the abnormally patterned output from GPi would not result from increased differential inhibitory/excitatory input arising from the direct/indirect pathway but rather be transmitted from GPe, striatum, or either centromedian nucleus. © 2003 Movement Disorder Society
Title: Neuronal globus pallidus activity in patients with generalised dystonia
Description:
AbstractWe studied 516 globus pallidus neurons in dystonic patients.
The firing rate was analysed.
We classified the burst activity into tonic, burst, and pause patterns.
Mean ± SD firing rates and tonicity score for internal globus pallidus (GPi) and external globus pallidus (GPe) were 54.
6 ± 28.
6; 58.
01 ± 39.
1 and 1.
18 ± 0.
55; 0.
95 ± 0.
43, respectively.
Differences in percentage appearance of tonic, burst, or paused neurons were not statistically significant for GPi versus GPe.
GPi firing features in dystonic patients were closely similar to those of GPe.
This could suggest that the abnormally patterned output from GPi would not result from increased differential inhibitory/excitatory input arising from the direct/indirect pathway but rather be transmitted from GPe, striatum, or either centromedian nucleus.
© 2003 Movement Disorder Society.
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