<b>Assessment of Tissue Perfusion in Brain Tumor Using CT Perfusion Imaging</b>

Background: Brain tumor grading is essential for treatment planning and prognosis, but conventional imaging may not fully characterize tumor vascularity and biological aggressiveness. CT perfusion imaging provides functional information through cerebral blood volume, cerebral blood flow, mean transit time, and perfusion score. Objective: To evaluate CT perfusion imaging parameters in patients with brain tumors and assess their association with tumor grade. Methods: This hospital-based analytical cross-sectional study included 100 patients with clinically or radiologically suspected brain tumors. CT perfusion parameters were categorized as normal or abnormal and compared between low-grade and high-grade tumors using chi-square testing. Results: Of 100 patients, 66 had low-grade and 34 had high-grade tumors. Abnormal CBV was observed in 55.9% of high-grade tumors compared with 42.4% of low-grade tumors (p=0.201). Abnormal perfusion score was present in 61.8% of high-grade tumors compared with 45.5% of low-grade tumors (p=0.122). Abnormal CBF and MTT showed minimal differences between groups, with p-values of 0.780 and 0.905, respectively. Conclusion: CT perfusion showed directional trends toward greater perfusion abnormality in high-grade tumors, particularly for CBV and perfusion score, but findings were not statistically significant. CT perfusion may provide adjunctive functional information, but larger studies using continuous parameters are required