Association between Bisphenol A exposure and dilated cardiomyopathy

Abstract Background Evidence has identified bisphenol A to have detrimental environmental and health effects. There are few studies on the association between bisphenol A exposure and cardiovascular abnormalities including cardiomyopathies and cardiac arrhythmias. Aim: Evaluation of the prevalence of bisphenol A exposure in patients with dilated cardiomyopathy versus healthy controls. Methods The study was a 1-year cross-sectional, single tertiary care cardiac centre, open-labeled, randomized, controlled study. Participants with dilated cardiomyopathy were included, while participants with ischemic cardiomyopathy were excluded. Eighty consecutive participants were selected and divided into 2 groups of 50 participants with dilated cardiomyopathy and 30 age and gender matched healthy participants and underwent transthoracic echocardiography. Results In the dilated cardiomyopathy group, bisphenol A was detected in 24% of the study participants, while in the healthy control group, bisphenol A was detected in 6.7%. There was a statistically significant weak association between bisphenol A exposure and dilated cardiomyopathy. In the dilated cardiomyopathy group, there was a statistically significant difference in the left atrial diameter and a highly significant difference in the tricuspid annular plane systolic excursion of the study participants exposed to bisphenol A versus not exposed to bisphenol A, and a highly significant strong association between bisphenol A exposure and right ventricular dilatation. Conclusions The prevalence of bisphenol A exposure was more in patients with dilated cardiomyopathy versus healthy controls and the volumetric indexes of the left atrial diameter and the right ventricular size and function were worse in patients with dilated cardiomyopathy exposed to bisphenol A versus patients with dilated cardiomyopathy not exposed to bisphenol A.