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Diminution of Proliferation, Migration, and Invasion of Melanoma Cells by Arctium Lappa L. Extracts
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As a highly aggressive form of human cancer, melanoma is prone to metastasis, leading to 75% of all skin cancer deaths. The 5-year-survival rate of melanoma is below 20%. Therefore, new therapies for melanoma are urgently needed. Burdock (Arctium lappa L) root - known for its antitumor, antioxidant, anti-inflammatory, antiviral, neuroprotective, and endoplasmic reticulum stress regulatory effects - was evaluated for its effects on the proliferation and apoptosis of melanoma cells and its possible mechanism. The results show suppression of the proliferation and stimulation of apoptosis of A375 cells in vitro. Additionally, it suppressed the PI3K/AKT pathway in A375 cells. These data suggest burdock (A. lappa L) root preparation as a promising drug for the treatment of melanoma.
New Century Health Publishers LLC
Title: Diminution of Proliferation, Migration, and Invasion of Melanoma Cells by Arctium Lappa L. Extracts
Description:
As a highly aggressive form of human cancer, melanoma is prone to metastasis, leading to 75% of all skin cancer deaths.
The 5-year-survival rate of melanoma is below 20%.
Therefore, new therapies for melanoma are urgently needed.
Burdock (Arctium lappa L) root - known for its antitumor, antioxidant, anti-inflammatory, antiviral, neuroprotective, and endoplasmic reticulum stress regulatory effects - was evaluated for its effects on the proliferation and apoptosis of melanoma cells and its possible mechanism.
The results show suppression of the proliferation and stimulation of apoptosis of A375 cells in vitro.
Additionally, it suppressed the PI3K/AKT pathway in A375 cells.
These data suggest burdock (A.
lappa L) root preparation as a promising drug for the treatment of melanoma.
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