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Desulfonylative Arylation of Redox-Active Alkyl Sulfones with Aryl Bromides
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Herein we describe the development of the first
reductive cross-electrophile coupling between alkyl sulfones and aryl bromides.
The use of alkyl sulfones as coupling partners offers strategic advantages over
other alkyl electrophiles used in reductive coupling reactions, as the sulfone moiety
can be incorporated into molecules in unique ways and permits α-functionalization
prior to coupling. The conditions developed here can be applied to incorporate
a wide array of aromatic rings onto (fluoro)alkyl scaffolds with broad
functional group tolerance and generality, making this a practical method for
late-stage diversification.
Title: Desulfonylative Arylation of Redox-Active Alkyl Sulfones with Aryl Bromides
Description:
Herein we describe the development of the first
reductive cross-electrophile coupling between alkyl sulfones and aryl bromides.
The use of alkyl sulfones as coupling partners offers strategic advantages over
other alkyl electrophiles used in reductive coupling reactions, as the sulfone moiety
can be incorporated into molecules in unique ways and permits α-functionalization
prior to coupling.
The conditions developed here can be applied to incorporate
a wide array of aromatic rings onto (fluoro)alkyl scaffolds with broad
functional group tolerance and generality, making this a practical method for
late-stage diversification.
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