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Inhibitory Effects of Gymnema (Gymnema sylvestre) Leaves on Tumour Promotion in Two‐Stage Mouse Skin Carcinogenesis
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Ethanol extracts of gymnema (Gymnema sylvestre) leaves exhibited marked antitumour‐promoting activity in an in vivo two‐stage carcinogenesis test in mice using 7,12‐dimethylbenz[a]anthracene as an initiator and 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA) as a promoter. From the active fraction of the ethanol extract of the gymnema leaves, three triterpenoids were isolated and identified. These compounds were evaluated for their inhibitory effects on TPA‐induced inflammation (1 µg/ear) in mice. The tested compounds showed marked anti‐inflammatory effects, with a 50% inhibitory dose of 50–555 nmol/ear.
Title: Inhibitory Effects of Gymnema (Gymnema sylvestre) Leaves on Tumour Promotion in Two‐Stage Mouse Skin Carcinogenesis
Description:
Ethanol extracts of gymnema (Gymnema sylvestre) leaves exhibited marked antitumour‐promoting activity in an in vivo two‐stage carcinogenesis test in mice using 7,12‐dimethylbenz[a]anthracene as an initiator and 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA) as a promoter.
From the active fraction of the ethanol extract of the gymnema leaves, three triterpenoids were isolated and identified.
These compounds were evaluated for their inhibitory effects on TPA‐induced inflammation (1 µg/ear) in mice.
The tested compounds showed marked anti‐inflammatory effects, with a 50% inhibitory dose of 50–555 nmol/ear.
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