Exploring the Convergence of Nanomedicine Application in Organoid Research Through a Scientometric Overview of Publications from 2015-2025

The convergence of nanomedicine and organoid technology has emerged as a promising frontier in biomedical science, offering improved platforms for disease modelling, drug testing, and precision therapy. However, the interdisciplinary landscape of this research remains underexplored. This study conducted a scientometric analysis of over 300 Scopus-indexed publications from 2015 to 2025 to characterize trends, collaborations, and thematic structures at the intersection of nanomedicine and organoid research. Using VOSviewer, we analyzed keyword co-occurrences, citation networks, and international co-authorships. Results reveal a substantial increase in publications over the past decade, with notable surges in topics such as tumor microenvironment, immune checkpoint therapy, and RNA sequencing. Core themes identified include tissue engineering, oncology modelling, regenerative medicine, and transcriptomics. The United States and China emerged as leading contributors, with growing global collaboration patterns. Keyword evolution analysis indicated a shift from foundational 3D culture and material optimization to more application-driven focuses in personalized medicine and environmental nanotoxicology. These findings highlight the field’s maturation into a multidisciplinary and translational domain. This overview provides valuable insights for guiding future research directions, international partnerships, and the development of clinically relevant organoid-based nanomedicine platforms.