GW24-e1863 The influence of benazepril hydrochloride on hypertensive left ventricular hypertrophy transmural heterogeneity of ventricular repolarisation

Objectives To study the relationship of Benazepril on hypertensive left ventricular hypertrophy transmural repolarisation heterogeneity effects and inhibit ventricular arrhythmias Methods Making hypertensive left ventricular hypertrophy model in rabbits, and to give Benazepril intervention, then determined the ventricular fibrillation threshold (VFT) and the epicardium, midmyocardium and endocardial myocardial monophasic action potential duration at 90% repolarisation (APD90), transmural dispersion of repolarisation (TDR). Results Compared with the control group, the treatment group VFT threshold was elevated, three myocardial layers in the middle layer of APD was shortened, myocardial APD was shorter than that of TDR, decrease. Benazepril group compared with the control group, no significant differences were found in VFT, APD90, TDR in three myocardial layers. Conclusions Benazepril can inhibit left ventricular hypertrophy and ventricular arrhythmia, indirectly reducing mistress layer myocardial transmural repolarisation heterogeneity.