Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
CC Chemokine Ligand-2: A Promising Target for Overcoming Anticancer Drug Resistance
View through CrossRef
CC chemokine ligand-2 (CCL2), a proinflammatory chemokine that mediates chemotaxis of multiple immune cells, plays a crucial role in the tumor microenvironment (TME) and promotes tumorigenesis and development. Recently, accumulating evidence has indicated that CCL2 contributes to the development of drug resistance to a broad spectrum of anticancer agents, including chemotherapy, hormone therapy, targeted therapy, and immunotherapy. It has been reported that CCL2 can reduce tumor sensitivity to drugs by inhibiting drug-induced apoptosis, antiangiogenesis, and antitumor immunity. In this review, we mainly focus on elucidating the relationship between CCL2 and resistance as well as the underlying mechanisms. A comprehensive understanding of the role and mechanism of CCL2 in anticancer drug resistance may provide new therapeutic targets for reversing cancer resistance.
Title: CC Chemokine Ligand-2: A Promising Target for Overcoming Anticancer Drug Resistance
Description:
CC chemokine ligand-2 (CCL2), a proinflammatory chemokine that mediates chemotaxis of multiple immune cells, plays a crucial role in the tumor microenvironment (TME) and promotes tumorigenesis and development.
Recently, accumulating evidence has indicated that CCL2 contributes to the development of drug resistance to a broad spectrum of anticancer agents, including chemotherapy, hormone therapy, targeted therapy, and immunotherapy.
It has been reported that CCL2 can reduce tumor sensitivity to drugs by inhibiting drug-induced apoptosis, antiangiogenesis, and antitumor immunity.
In this review, we mainly focus on elucidating the relationship between CCL2 and resistance as well as the underlying mechanisms.
A comprehensive understanding of the role and mechanism of CCL2 in anticancer drug resistance may provide new therapeutic targets for reversing cancer resistance.
Related Results
The bovine chemokine receptors and their mRNA abundance in mononuclear phagocytes
The bovine chemokine receptors and their mRNA abundance in mononuclear phagocytes
AbstractBackgroundThe chemokine and chemokine receptor families play critical roles in both the healthy and diseased organism mediating the migration of cells. The chemokine system...
Chemokine sequestration by atypical chemokine receptors
Chemokine sequestration by atypical chemokine receptors
Leucocyte migration is essential for robust immune and inflammatory responses, and plays a critical role in many human diseases. Chemokines, a family of small secreted protein chem...
Evolution of Antimicrobial Resistance in Community vs. Hospital-Acquired Infections
Evolution of Antimicrobial Resistance in Community vs. Hospital-Acquired Infections
Abstract
Introduction
Hospitals are high-risk environments for infections. Despite the global recognition of these pathogens, few studies compare microorganisms from community-acqu...
Clinical significance of baseline and post-treatment CXCR1 expression in breast cancer women received neoadjuvant chemotherapy
Clinical significance of baseline and post-treatment CXCR1 expression in breast cancer women received neoadjuvant chemotherapy
Objective: To examine the chemokine receptor type 1 expression in breast cancer tissues before and after neoadjuvant chemotherapy, and its relationship with pathological response t...
Relationships Among Obesity, Type 2 Diabetes, and Plasma Cytokines in African American Women
Relationships Among Obesity, Type 2 Diabetes, and Plasma Cytokines in African American Women
ObjectiveThe principal objective of this investigation was to identify novel cytokine associations with BMI and type 2 diabetes (T2D).MethodsCytokines were profiled from African Am...
Prediction of Drug-Target Binding Kinetics for Flexible Proteins by Comparative Binding Energy Analysis
Prediction of Drug-Target Binding Kinetics for Flexible Proteins by Comparative Binding Energy Analysis
There is growing consensus that the optimization of the kinetic parameters for drug-protein binding leads to improved drug efficacy. Therefore, computational methods have been deve...
Prediction of Drug-Target Binding Kinetics for Flexible Proteins by Comparative Binding Energy Analysis
Prediction of Drug-Target Binding Kinetics for Flexible Proteins by Comparative Binding Energy Analysis
There is growing consensus that the optimization of the kinetic parameters for drug-protein binding leads to improved drug efficacy. Therefore, computational methods have been deve...
Diverse mutant selection windows shape spatial heterogeneity in evolving populations
Diverse mutant selection windows shape spatial heterogeneity in evolving populations
ABSTRACTMutant selection windows (MSWs), the range of drug concentrations that select for drug-resistant mutants, have long been used as a model for predicting drug resistance and ...