EFFECT OF <i>VITIS VINIFERA</i> ON MARBLE BURYING BEHAVIOUR IN MICE

Background: Approximately 2% of people worldwide suffer from obsessive-compulsive disorder, a common mental health issue. Although obsessive-compulsive disorder was thought to be among the rarest mental disorders in previous decades, research conducted in recent years has shown that it is really one of the most prevalent mental disorders. The use of grapes in traditional medicine has been supported by several scientific investigations. In this study, we assessed the effect of  Vitis vinifera on marble burying behaviour in mice Material and method: Every mouse was placed in a cage with usual dimensions of (22 x 32 x 13.5 cm) containing a 5 cm layer of sawdust and 24 glass marbles (1.5 cm in diameter). The test compound, the vehicle and fluoxetine, the standard drug, were administered and the animals were kept in the cages for next 30 min. The number of marbles buried in the sawdust, during 30 min, was recorded for every single mouse. Result: The results of the analysis reveal that the number of marbles buried by the mice were significantly decreased in the mice receiving Vitis vinifera juice as compared to saline treated group. The results are comparable to the standard drug, fluoxetine. Conclusion: Vitis vinifera juice has shown a significant effect on the marble burying behaviour in mice. In previous studies, Vitis vinifera has shown modulating effect on the amine neurotransmitters, especially, serotonin. This effect of the herb might be responsible for it effect on the marble burying behaviour of the mice.