Clinicopathological role and prognostic significance of intermedin expression in malignant pleural mesothelioma: a meta-analysis

Abstract Objective To study the clinicopathological role and prognostic significance of intermedin expression in malignant pleural mesothelioma. Methods Pubmed, EMBASE, CNKI and Wanfang databases were searched for articles published from January 2006 to the present. The key words used in Chinese search were malignant pleural mesothelioma and mesothelin, and the key words used in English search were malignant mesothelioma and mesothelin. A summary of the relevant literature was read, and the journal literature related to this study was screened out. Three investigators screened and extracted the literature data, conducted statistical analysis, recorded the search results and evaluated the quality, and analyzed the relationship between the high expression of mesothelin and the clinicopathological effect and prognostic significance of patients with malignant pleural mesothelioma. Results A total of 605 patients with malignant pleural mesothelioma were involved in the 7 literatures. According to the actual reference interval of the indicators, the cut-off value of serum mesothelin level was selected as 1.65nM, ≥ 1.65nM was recorded as high expression of mesothelin, < 1.65nM was recorded as low expression of mesothelin. High expression of mesothelin was associated with TNM stage (OR = 0.42, 95%CI: 0.26–0.66, P < 0.01), tumor invasion extent (OR = 0.58, 95%CI: 0.36–0.93, P < 0.05), and overall survival time (OR = 2.31, 95%CI: 1.47–3.65, P < 0.01). Conclusions The high expression of intermedin in malignant pleural mesothelioma has high clinicopathological and prognostic significance, which is worthy of clinical attention.