Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
The Association Study of Targeted DNA Methylation and Thrombophilia
View through CrossRef
Abstract
Objective
The aim of this study is to investigate the relationship of leukocytes DNA methylation in targeted sites and thrombophilia.
Methods
Eight thrombophilia patients and their kin-related individuals as the healthy control. Targeted DNA methylation from peripheral leukocytes were examined with MassArray. Multivariate correlation analysis was used to estimate targeted gene methylation as an independent risk factor of thrombophilia. Receiver operating characteristic curve analysis was used to calculate the accuracy of biomarkers in the prediction of thrombophilia.
Results
The age of thrombophilia group was higher than control group (P < 0.001). F5.24.CpG.10 and Protein S.44.CpG.29–33 methylation were significantly associated with thrombophilia negatively and positively (r = -0.7289, P < 0.01 and r = 0.5667, P < 0.05). F5.24.CpG.10 methylation was higher in control group (P < 0.01), but Protein S.44.CpG.29–33 methylation increased in thrombophilia group (P < 0.05). The areas under curve of ROC were 0.9297 and 0.8437, respectively.
Conclusion
Target DNA methylation in Protein S.44.CpG.29–33 island is associated with an elevated risk of thrombophilia.
Springer Science and Business Media LLC
Title: The Association Study of Targeted DNA Methylation and Thrombophilia
Description:
Abstract
Objective
The aim of this study is to investigate the relationship of leukocytes DNA methylation in targeted sites and thrombophilia.
Methods
Eight thrombophilia patients and their kin-related individuals as the healthy control.
Targeted DNA methylation from peripheral leukocytes were examined with MassArray.
Multivariate correlation analysis was used to estimate targeted gene methylation as an independent risk factor of thrombophilia.
Receiver operating characteristic curve analysis was used to calculate the accuracy of biomarkers in the prediction of thrombophilia.
Results
The age of thrombophilia group was higher than control group (P < 0.
001).
F5.
24.
CpG.
10 and Protein S.
44.
CpG.
29–33 methylation were significantly associated with thrombophilia negatively and positively (r = -0.
7289, P < 0.
01 and r = 0.
5667, P < 0.
05).
F5.
24.
CpG.
10 methylation was higher in control group (P < 0.
01), but Protein S.
44.
CpG.
29–33 methylation increased in thrombophilia group (P < 0.
05).
The areas under curve of ROC were 0.
9297 and 0.
8437, respectively.
Conclusion
Target DNA methylation in Protein S.
44.
CpG.
29–33 island is associated with an elevated risk of thrombophilia.
Related Results
Whole Exome Sequencing and Extended Thrombophilia Testing in Patients with Venous Thromboembolism
Whole Exome Sequencing and Extended Thrombophilia Testing in Patients with Venous Thromboembolism
Abstract
Introduction: Venous thromboembolism (VTE), defined as deep venous thrombosis (DVT) and pulmonary embolism (PE), is a cause of significant morbidity and mor...
Abstract A37: Aberrant DNA methylation of HTATIP2 and UCH-L1 as prognostic and predictive biomarkers for cholangiocarcinoma
Abstract A37: Aberrant DNA methylation of HTATIP2 and UCH-L1 as prognostic and predictive biomarkers for cholangiocarcinoma
Abstract
Cholangiocarcinoma (CCA) is a malignancy of bile duct epithelial cell lining. In the past decade, the incidence and mortality rates of CCA have been increas...
Abstract 2094: Correaltions between genome-wide DNA methylation profiles and genomic driver aberrations during multistage lung adenocaricinogenesis
Abstract 2094: Correaltions between genome-wide DNA methylation profiles and genomic driver aberrations during multistage lung adenocaricinogenesis
Abstract
The aim of this study was to clarify correlations between epigenomic and genomic alterations during multistage lung adenocarcinogenesis. Single-CpG resoluti...
Genome-Wide DNA Methylation Analysis Identifies Aberrant Epigenetic Changes in CD8+ T Cells from Chronic Lymphocytic Leukemia Patients
Genome-Wide DNA Methylation Analysis Identifies Aberrant Epigenetic Changes in CD8+ T Cells from Chronic Lymphocytic Leukemia Patients
Abstract
Background CD8+ T cells from chronic lymphocytic leukemia (CLL) patients have been demonstrated to exhibit a number of alterations in global gene expression...
Genome wide hypomethylation and youth-associated DNA gap reduction promoting DNA damage and senescence-associated pathogenesis
Genome wide hypomethylation and youth-associated DNA gap reduction promoting DNA damage and senescence-associated pathogenesis
Abstract
Background: Age-associated epigenetic alteration is the underlying cause of DNA damage in aging cells. Two types of youth-associated DNA-protection epigenetic mark...
Genome wide hypomethylation and youth-associated DNA gap reduction promoting DNA damage and senescence-associated pathogenesis
Genome wide hypomethylation and youth-associated DNA gap reduction promoting DNA damage and senescence-associated pathogenesis
Introduction: The United States currently faces two opioid crises, an evolved crisis currently manifesting as widespread abuse of illicit opioids, and a crisis in pain management l...
Whole-genome bisulfite sequencing of multiple individuals reveals complementary roles of promoter and gene body methylation in transcriptional regulation
Whole-genome bisulfite sequencing of multiple individuals reveals complementary roles of promoter and gene body methylation in transcriptional regulation
Abstract
Background
DNA methylation is an important type of epigenetic modification involved in gene regulation. Although strong DNA...
Abstract 1289: Crosstalk between methylation and alternative splicing in cancer
Abstract 1289: Crosstalk between methylation and alternative splicing in cancer
Abstract
Background: DNA methylation in promoter regions leads to transcriptional silencing, such as of tumor suppressor genes in cancer. However, the functions of D...