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Age-dependent, polyclonal hyperactivation of T cells is reduced in TNF-negativegld/gldmice
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AbstractThe generalized lymphoproliferative disorder (gld) mouse strain is characterized by severe splenomegaly/lymphadenopathy, the production of autoimmune antibodies, and the appearance of CD4/CD8-negative T cells. An additional TNF deficiency of gld/gld mice attenuates the course of the disorder through a yet-unknown mechanism. In this study, we could demonstrate that the reduced splenomegaly and lymphadenopathy in B6.gld/gld.TNF−/− mice were correlated with a decreased peripheral T cell proliferation rate and a delayed polyclonal activation. A comparative analysis of naïve T cells and memory/effector T cells showed an age-dependent difference in the T cell activation pattern in the spleen of B6.gld/gld and B6.gld/gld.TNF−/− mice. T cells from B6.gld/gld.TNF−/− spleens and lymph nodes showed significantly higher levels of CCR7 and CD62 ligand on their surface compared with B6.gld/gld mice when mice of the same age were compared. Additionally, we found an increased titer of the Th1 cytokine IFN-γ in the serum of B6.gld/gld mice, whereas the concentration of IFN-γ was markedly reduced in the serum of B6.gld/gld.TNF−/− mice. These findings support the hypothesis that increased T cell activation and proliferation in the presence of TNF contribute to the exacerbation of the gld syndrome.
Oxford University Press (OUP)
Title: Age-dependent, polyclonal hyperactivation of T cells is reduced in TNF-negativegld/gldmice
Description:
AbstractThe generalized lymphoproliferative disorder (gld) mouse strain is characterized by severe splenomegaly/lymphadenopathy, the production of autoimmune antibodies, and the appearance of CD4/CD8-negative T cells.
An additional TNF deficiency of gld/gld mice attenuates the course of the disorder through a yet-unknown mechanism.
In this study, we could demonstrate that the reduced splenomegaly and lymphadenopathy in B6.
gld/gld.
TNF−/− mice were correlated with a decreased peripheral T cell proliferation rate and a delayed polyclonal activation.
A comparative analysis of naïve T cells and memory/effector T cells showed an age-dependent difference in the T cell activation pattern in the spleen of B6.
gld/gld and B6.
gld/gld.
TNF−/− mice.
T cells from B6.
gld/gld.
TNF−/− spleens and lymph nodes showed significantly higher levels of CCR7 and CD62 ligand on their surface compared with B6.
gld/gld mice when mice of the same age were compared.
Additionally, we found an increased titer of the Th1 cytokine IFN-γ in the serum of B6.
gld/gld mice, whereas the concentration of IFN-γ was markedly reduced in the serum of B6.
gld/gld.
TNF−/− mice.
These findings support the hypothesis that increased T cell activation and proliferation in the presence of TNF contribute to the exacerbation of the gld syndrome.
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