Protocol for PRP Therapy with Physiotherapy for Shoulder Adhesive Capsulitis v1

Background and Purpose: Adhesive capsulitis, or frozenshoulder, leads to pain and reduced mobility due to joint inflammation andfibrosis. While physiotherapy is the standard treatment, recovery is often aslow process. Platelet-rich plasma (PRP), rich in growth factors, may enhancehealing. This study aims to evaluate the effectiveness of Platelet-Rich Plasmain combination with physiotherapy on biomarkers, soft tissue morphology, andfunction in patients with shoulder adhesive capsulitis. Methods: From June to December 2025, a double-blindedrandomized control trial will be conducted at Jashore University of Science andTechnology, Bangladesh, enrolling 60 patients with shoulder adhesivecapsulitis. Participants will be randomly assigned to either PRP withphysiotherapy (experimental) or sham PRP with physiotherapy (control),receiving 24 therapy sessions over 6 weeks. Primary outcomes include painsensitivity, blood cell counts from synovial fluid, and soft tissue morphology.The secondary outcome is functional ability measured by Shoulder Pain andDisability Index (SPADI) at multiple time points. Ethical approval and trialregistration will be obtained, and ICH-GCP guidelines will be followed. Alladverse effects will be monitored and reported. Discussion: The findings from this trialwill highlight the synergistic effects of platelet-rich plasma (PRP) andphysiotherapy in managing adhesive capsulitis. By addressing both thebiological and mechanical contributors to the condition, the combinedintervention could offer greater improvements in pain modulation, soft-tissuerestoration, and functional outcomes compared to physiotherapy alone. Notably,changes in blood biomarkers and soft-tissue morphology may provide deeperinsight into the therapeutic mechanisms of PRP. These results could informfuture integrative rehabilitation protocols and support more personalizedapproaches to frozen shoulder management. However, long-term effects,cost-effectiveness, and broader applicability should be explored in futurestudies. Conclusion: This study will provideessential evidence on the effectiveness of PRP therapy in evaluating musclemorphology and improving functional recovery in patients with adhesivecapsulitis. The findings will contribute to advancing diagnostic accuracy,optimizing treatment strategies, and enhancing future research in musculoskeletalrehabilitation.Background and Purpose: Adhesive capsulitis, or frozenshoulder, leads to pain and reduced mobility due to joint inflammation andfibrosis. While physiotherapy is the standard treatment, recovery is often aslow process. Platelet-rich plasma (PRP), rich in growth factors, may enhancehealing. This study aims to evaluate the effectiveness of Platelet-Rich Plasmain combination with physiotherapy on biomarkers, soft tissue morphology, andfunction in patients with shoulder adhesive capsulitis. Methods: From June to December 2025, a double-blindedrandomized control trial will be conducted at Jashore University of Science andTechnology, Bangladesh, enrolling 60 patients with shoulder adhesivecapsulitis. Participants will be randomly assigned to either PRP withphysiotherapy (experimental) or sham PRP with physiotherapy (control),receiving 24 therapy sessions over 6 weeks. Primary outcomes include painsensitivity, blood cell counts from synovial fluid, and soft tissue morphology.The secondary outcome is functional ability measured by Shoulder Pain andDisability Index (SPADI) at multiple time points. Ethical approval and trialregistration will be obtained, and ICH-GCP guidelines will be followed. Alladverse effects will be monitored and reported. Discussion: The findings from this trialwill highlight the synergistic effects of platelet-rich plasma (PRP) andphysiotherapy in managing adhesive capsulitis. By addressing both thebiological and mechanical contributors to the condition, the combinedintervention could offer greater improvements in pain modulation, soft-tissuerestoration, and functional outcomes compared to physiotherapy alone. Notably,changes in blood biomarkers and soft-tissue morphology may provide deeperinsight into the therapeutic mechanisms of PRP. These results could informfuture integrative rehabilitation protocols and support more personalizedapproaches to frozen shoulder management. However, long-term effects,cost-effectiveness, and broader applicability should be explored in futurestudies. Conclusion: This study will provideessential evidence on the effectiveness of PRP therapy in evaluating musclemorphology and improving functional recovery in patients with adhesivecapsulitis. The findings will contribute to advancing diagnostic accuracy,optimizing treatment strategies, and enhancing future research in musculoskeletalrehabilitation.