Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Anakinra treatment for refractory cerebral autoinflammatory responses
View through CrossRef
Abstract
Refractory cerebral autoinflammatory–autoimmune diseases are often associated with dysregulated innate immunity and are targeted by anakinra, an interleukin‐1 receptor antagonist. We analyzed the therapeutic effect of anakinra in refractory cerebral autoinflammatory response (CAIR) at a single institution from January 2017 to May 2021. In total, 12 patients with various etiologies were sympathetically treated with anakinra (100 mg/day subcutaneously). Four patients showed good responses, and among these patients, three patients had pathologically demonstrated CAIR. The other eight patients were nonresponsive. No patient had a serious adverse effect. Thus, anakinra may be a therapeutic option for refractory cerebral autoinflammatory diseases.
Title: Anakinra treatment for refractory cerebral autoinflammatory responses
Description:
Abstract
Refractory cerebral autoinflammatory–autoimmune diseases are often associated with dysregulated innate immunity and are targeted by anakinra, an interleukin‐1 receptor antagonist.
We analyzed the therapeutic effect of anakinra in refractory cerebral autoinflammatory response (CAIR) at a single institution from January 2017 to May 2021.
In total, 12 patients with various etiologies were sympathetically treated with anakinra (100 mg/day subcutaneously).
Four patients showed good responses, and among these patients, three patients had pathologically demonstrated CAIR.
The other eight patients were nonresponsive.
No patient had a serious adverse effect.
Thus, anakinra may be a therapeutic option for refractory cerebral autoinflammatory diseases.
Related Results
Anakinra Treatment for Refractory Cerebral Autoinflammatory Responses
Anakinra Treatment for Refractory Cerebral Autoinflammatory Responses
Abstract
BackgroundRefractory cerebral autoinflammatory-autoimmune diseases are often associated with dysregulated innate immunity, which are targeted by anakinra, an inter...
Efficacy of anakinra treatment in pediatric rheumatic diseases: Our single-center experience
Efficacy of anakinra treatment in pediatric rheumatic diseases: Our single-center experience
Objectives: This study aims to present our experience on anakinra, a recombinant interleukin-1 (IL-1) receptor antagonist, and efficacy results in pediatric rheumatic diseases in o...
Determinants of Cerebrovascular Reserve in Patients with Significant Carotid Stenosis
Determinants of Cerebrovascular Reserve in Patients with Significant Carotid Stenosis
Abstract
Introduction
In patients with 70% to 99% diameter carotid artery stenosis cerebral blood flow reserve may be protectiv...
Anakinra reduces lung inflammation in experimental acute lung injury
Anakinra reduces lung inflammation in experimental acute lung injury
AbstractIntroductionAcute respiratory distress syndrome (ARDS) is a severe form of acute lung injury (ALI) resulting in life‐threatening hypoxaemia. Although ARDS can be caused by ...
Schnitzler syndrome: response to anakinra in two cases and a review of the literature
Schnitzler syndrome: response to anakinra in two cases and a review of the literature
AbstractBackground Schnitzler syndrome is a rare disease characterized by a chronic urticarial eruption and monoclonal gammopathy, as well as clinical and laboratory signs of infl...
Pathophysiology of COVID-19 and Autoimmune and Autoinflammatory Diseases: Acute Infectious Systemic Inflammatory Process on Underlying Chronic Non-Infectious Systemic Inflammatory Process. A Literature Review
Pathophysiology of COVID-19 and Autoimmune and Autoinflammatory Diseases: Acute Infectious Systemic Inflammatory Process on Underlying Chronic Non-Infectious Systemic Inflammatory Process. A Literature Review
The occurrence of COVID-19 in the context of autoimmune or autoinflammatory disease prompts practitioners involved in the management of these conditions to investigate the pathophy...
Acquired autoinflammatory disorders: a dermatologist’s perspective
Acquired autoinflammatory disorders: a dermatologist’s perspective
Abstract
Autoinflammatory disorders are characterized by a dysregulated and disproportionately heightened response by the innate immune system to PAMPs and DAMPs (pa...
Hybrid diffuse optical neuromonitoring of cerebral haemodynamics: from the smallest premature born infants to adults
Hybrid diffuse optical neuromonitoring of cerebral haemodynamics: from the smallest premature born infants to adults
Hybrid diffuse optical devices allows for the non-invasive and continuous monitoring of the cerebral haemodynamics and metabolism. Such devices can be portable and are relatively i...