Pentadecapeptide BPC 157 counteracts celecoxib‐induced lesions on gastric mucosa in rats (840.6)

Aim: We investigated the anti‐ulcer effect of pentadecapeptide BPC 157, after celecoxib overdose. Methods: Gastric mucosal injuries in rats were induced by celecoxib (1g/kg) intraperitoneally. To counteract, BPC 157 (10 µg, 10 ng (/kg)) or saline (5ml/kg) were given intraperitoneally immediately thereafter. Rats were sacrificed after 24 and 48 hours, and stomach mucosal defects were assessed as described (Curr Pharm Des 2013;19(1):76‐83). Results: Celecoxib induced huge gastric lesions, huge confluent lesions (4±1 (48h)), and multitude of punctiforming black hemorrhagic lesions (20±3 (24h), 30±5 (48h)), that were both counteracted in BPC 157 rats (no confluent lesions, no punctiform lesions at 24h, punctiform lesions at 48h: 4±2 (µg);10±3 (ng)). Conclusions: Celecoxib induces in overdose huge gastric lesions. BPC 157 was able to counteract lesion formation. This effect is along with counteraction of the lesions induced by nonselective NSAIDs (Curr Pharm Des 2013;19(1):76‐83). Grant Funding Source : 108‐1083570‐3635, Ministry of Science, Education and Sports, Croatia