Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Stable ditriflates of D-glucose in the synthesis of iminosugars and polyhydroxyolated pipecolic acids
View through CrossRef
A synthesis of the five membered iminosugar DAB and a divergent synthesis of the six membered iminosugar 1-dehydromannojirimycin (DMJ) and the corresponding sugar iminoacid are reported. They involve double nucleophilic displacements of a D-xylose ditriflate by benzyl carbazate and a D-glucose ditriflate by allyl amine, respectively. They are followed by a similar protocol consisting of hydrolysis and oxidation or reduction of the resulting bicyclic glycosides. This allowed DMJ to be obtained from the cheap sugar D-glucose.
American Chemical Society (ACS)
Title: Stable ditriflates of D-glucose in the synthesis of iminosugars and polyhydroxyolated pipecolic acids
Description:
A synthesis of the five membered iminosugar DAB and a divergent synthesis of the six membered iminosugar 1-dehydromannojirimycin (DMJ) and the corresponding sugar iminoacid are reported.
They involve double nucleophilic displacements of a D-xylose ditriflate by benzyl carbazate and a D-glucose ditriflate by allyl amine, respectively.
They are followed by a similar protocol consisting of hydrolysis and oxidation or reduction of the resulting bicyclic glycosides.
This allowed DMJ to be obtained from the cheap sugar D-glucose.
Related Results
Amino Acids, Survey
Amino Acids, Survey
AbstractAmino acids are the main components of proteins. Approximately 20 amino acids are common constituents of proteins and are called protein amino acids, or primary protein ami...
Amino Acids
Amino Acids
AbstractAmino acids are the main components of proteins. Approximately 20 amino acids are common constituents of proteins and are called protein amino acids, or primary protein ami...
Pregnancy and Challenging Transient Anti-GAD65 Positivity: A Case Report with Literature Review
Pregnancy and Challenging Transient Anti-GAD65 Positivity: A Case Report with Literature Review
Abstract
Introduction
During pregnancy, women may develop blood glucose abnormalities like gestational diabetes mellitus (GDM) or, rarely, type 1 diabetes (T1D), which can lead to ...
Methodology development for the synthesis of iminosugars
Methodology development for the synthesis of iminosugars
<p>This thesis investigated the development and application of methodology for the synthesis of iminosugars. The first portion of this thesis (Chapters 2 and 3) explored the ...
Methodology development for the synthesis of iminosugars
Methodology development for the synthesis of iminosugars
<p>This thesis investigated the development and application of methodology for the synthesis of iminosugars. The first portion of this thesis (Chapters 2 and 3) explored the ...
Metabolism in compensatory growth: VI. Effect of energy yielding substrates
Metabolism in compensatory growth: VI. Effect of energy yielding substrates
An experiment was designed to investigate the effect of different rates of glucose infusion into animals fed a maintenance diet supplemented with undegraded protein (HCHO-casein). ...
Intravenous glucose infusion affects nitrogen retention in sheep
Intravenous glucose infusion affects nitrogen retention in sheep
To investigate the effect of intravenous glucose infusion on nitrogen (N) retention, two experiments were conducted in 2 phases . The first phase (Exp 1) was to establish the time ...
Bioinformatics Analysis of Gefitinib or Rapamycin on Inhibiting the Survival of Hela in the Low Glucose and High Lactic Acid Environment
Bioinformatics Analysis of Gefitinib or Rapamycin on Inhibiting the Survival of Hela in the Low Glucose and High Lactic Acid Environment
Objective: To explore on the antitumor effect of gefitinib and rapamycin and possible mechanism in normal glucose and high lactic acid microenvironment. Methods: Hela cells are cul...