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Comparison of the cobas Human Immunodeficiency Virus 1 (HIV-1) Test Using the cobas 4800 System With COBAS AmpliPrep/COBAS TaqMan HIV-1 Test and Abbott RealTime HIV-1 Assay and Performance Evaluation of cobas HIV-1
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Abstract
Objectives
To compare quantified human immunodeficiency virus type 1 (HIV-1) viral load quantified using the cobas HIV-1 test with that obtained using the CAP/CTM HIV-1 and Abbott RealTime HIV-1 tests and evaluate the performance of cobas HIV-1 using the cobas 4800 system.
Methods
Clinical samples (n = 123) were quantitatively analyzed using the CAP/CTM HIV-1, Abbott RealTime HIV-1, and cobas HIV-1 tests, and the precision, linearity, and limit of detection of the cobas HIV-1 test were evaluated.
Results
Comparable results were obtained by both methods: ([log CAP/CTM HIV-1 value] = 0.979 * [log cobas HIV-1 test value] + 0.034) and ([log Abbott RealTime HIV-1 value] = 0.985 * [log cobas HIV-1 test value] + 0.027). cobas HIV-1 test results for 89.4% and 93.5% were within 0.5 log10 IU/mL of the CAP/CTM HIV-1 and Abbott RealTime HIV-1 results, respectively.
Conclusions
The cobas HIV-1 test showed good performance, and its results correlated well with those of other two tests.
Oxford University Press (OUP)
Title: Comparison of the cobas Human Immunodeficiency Virus 1 (HIV-1) Test Using the cobas 4800 System With COBAS AmpliPrep/COBAS TaqMan HIV-1 Test and Abbott RealTime HIV-1 Assay and Performance Evaluation of cobas HIV-1
Description:
Abstract
Objectives
To compare quantified human immunodeficiency virus type 1 (HIV-1) viral load quantified using the cobas HIV-1 test with that obtained using the CAP/CTM HIV-1 and Abbott RealTime HIV-1 tests and evaluate the performance of cobas HIV-1 using the cobas 4800 system.
Methods
Clinical samples (n = 123) were quantitatively analyzed using the CAP/CTM HIV-1, Abbott RealTime HIV-1, and cobas HIV-1 tests, and the precision, linearity, and limit of detection of the cobas HIV-1 test were evaluated.
Results
Comparable results were obtained by both methods: ([log CAP/CTM HIV-1 value] = 0.
979 * [log cobas HIV-1 test value] + 0.
034) and ([log Abbott RealTime HIV-1 value] = 0.
985 * [log cobas HIV-1 test value] + 0.
027).
cobas HIV-1 test results for 89.
4% and 93.
5% were within 0.
5 log10 IU/mL of the CAP/CTM HIV-1 and Abbott RealTime HIV-1 results, respectively.
Conclusions
The cobas HIV-1 test showed good performance, and its results correlated well with those of other two tests.
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