THE AUSTRALIAN RHEUMATOLOGY ASSOCIATION

The followina are abstracts of papers presented at the 35th Annual Scientific Meeting of the Australian Rheumatology Association, held in Perth, Western Australia, 1–4 December. 1991PREVENTlON OF CORTICOSTEROID OSTEOPOROSIS, P.N. Sambrook*, J. Birmingham, P. Kelly, T. Nguyen, N. Pocock, J. A. EismanRHEUMATOID ARTHRITIS IN TWINS BASED ON THE AUSTRALIAN TWIN REGISTRY (ATR), N. Bellamy*, D. Duffy2, N. Martin2 and J. Matrhews3. 1Epidemiology and BiostatirticsHEPARIN, PENTOSAN POLYSULPHATE AND DEXTRAN SULPHATE TRIGGER TYPE I COLLAGEN‐INDUCED VASCULAR TUBE FORMATION IN VITRO. Chris Jackson, Irina Giles, Andrew Nethery and Les SchrieberTHE T‐CELL ANTIGEN RECEPTOR CLONOTYPIC CHAINS INTERACT VIA DISTINCT REGIONS WITH THE CD3 CHAINS. N. Manolios*, F. Letourner, J. Bonifacino and R. KlausnerMIMICRY VERSUS SELF IMMUNIZATION: DEFINITION OF A DlSCONTINUOUS EPITOPE AT THE N‐TERMINUS OF THE La(SS‐B) RIBONUCLEOPROTETN ANTIGEN. L. J. McNeilage, K. Umapathysivam and T. GordonMETABOLISM OF ARTICULAR CARTILAGE IN AN EXPERIMENTAL MODEL OF EARLY OSTEO‐ARTHRITIS. P. Ghosh*, Y. Numata, S. Smith, R. Read+ and S. Armstrong+FIBROMYALGIA SYNDROME ‐ A RHEUMATAUTOLOGY. Milton L. CohenTHE CHONDROPROTECTIVE DRUGS, PENTOSAN POLYSULFATE AND ARTEPARON, STIMULATE COLLAGENASE AND INHIBIT STROMELYSIN ACTIVITIES IN VITRO. Andrew Nethery*1, Irina Giles1, Leslie Schrieber1, Peter Brooks1 Dan Burkhardt2, Peter Ghosh2, Robert L. O'Grady3, and Howard G. Welgus4THE EFFECTS OF ORAL ADMINISTRATION OF CALCIUM PENTOSAN POLYSULPHATE (CaPPS) ON CARTILAGE AND SYNOVIAL FLUID COMPONENTS IN A RABBIT MODEL OF INFLAMMATORY ARTHRITIS. M. Smith* and P. GhoshINCREASED SYNOVIAL FLUID KERATAN SULPHATE CONCENTRATION AND FLUX OCCUR FOLLOWING TREATMENT OF OSTEOARTHRITIS OF THE KNEE WITH INDOMETHACIN AND AZAPROPAZONE. B Will*, C. Caspersz, J. Barnes, N. HallTHE USE OF KERATAN SULPHATE (KS) EPITOPES IN SYNOVIAL FLUID AS AN INDEX OF CARTILAGE INTEGRITY IN EARLY OA AND AS A MARKER OF RESPONSE TO DRUG THERAPY. P. Ghosh*, C. Holbert, C. Wells, S. Armstrong*, P. Wilson+ and R. Read+EFFECTS OF NEUROPEPTIDES ON ARTICULAR CARTILAGE CHONDROCYTE FUNCTION. Dale A. Halliday, Julian D. McNell, *W. H. Betts & + Raffaele ScicchitanoIDIOPATHIC CHONDROLYSlS OF THE HIP Case Report and Studies on Chrondrocyte Proteoalycan Metabolism G.A.C. MAJOR*, J. MELROSE**, A. JACOBY**, P. GHOSH**ACTIVATION OF THE MACROPHAGE RESPIRATORY BURST CORRELATES WITH PROTEIN TYROSINE KINASE‐MEDIATED PHOSPHORYLATION Simon P. Green, Wayne A. Phillips, and John A. HamiltonTHE KINETICS OF SYNOVIAL HYALURONAN (HYALURONIC ACID; HA) IN NORMAL AND ACUTELY INFLAMED JOINTS. JRE Fraser*, TJ Brown*, WG Kimpton*, UBG Laurent† and BK Pierscionek*ACTIVATION OF NEUTROPHILS BY TACHYKININS: EFFECTS ON OXIDATIVE METABOLISM AND ANTIBODY‐DEPENDENT CELL‐MEDlATED CYTOTOXICITY. A Wozniak*, R Scicchitano§ and WH BettsDETERMINANTS OF SYNOVIAL FLUID LACTATE CONCENTRATION. M. J. James* and L. G. ClelandCOLLAGEN ANTIBODIES IN EARLY ARTHRITIS M. J. Rowley1*, A. Stockman2, C. A. Brand2, K. D. Muirden2, I. R. Mackay1REGULATION OF ANTI‐FIBRINOLYTIC ACTIVITY IN MONOCYTIC CELLS. J. L. Dickinson and T. M. Antalis*IgG SUBCLASSES OF COLLAGEN ANTIBODIES M. J. Rowley*Analysis of TNFα and IL‐1β and their inhibitors in Rheumatoid and Osteoarthritic synovial tissue by Immunohistochemistry and by Bioassay and ELISA of Explant cultures. V. Milwav, K. Rogers and K. D. MuirdenFIBROBLAST GROWTH FACTORS IN CONNECTIVE TISSUE DISEASE ASSOCIATED INTERSTITIAL LUNG DISEASE: ASSOCIATION WITH DISEASE ACTlVlTY AND IDENTlFlCATlON AS TNF‐α, PDGF AND FIBRONECTIN. S. C. Thornton*, R. Penny and S. N. BreitDETECTION OF COLONY‐STIMULATING ACTIVITY IN SYNOVIAL FLUID IN MULTICENTRIC RETICULOHISTIOCYTOSlS. Michael J. Elliott*; David A Kmdiah and David BarracloughEFFECT OF GONADAL STEROIDS ON THE PRODUCTlON OF INTERLEU‐KIN‐1 AND INTERLEUKIN‐6 BY PERIPHERAL BLOOD MONONUCLEAR CELLS IN VITRO. ZG Li*, VA Danis and PM BrooksFAMILY STUDIES IN AUTOIMMUNOLOGY A STUDY USING A RECOMBINANT SS.B/La R. Owe‐Young and A. SturgessREACTIVITY OF HUMAN AUTOANTIBODIES TO THE RNA BINDING DOMAIN OF THE La(SS‐B) RIBONUCLEOPROTEIN AUTOANTIGEN. M. Rischmueller, L. J. McNeilage, K. Umapathysivam and T. GordonUSE OF A MOLECULARLY CLONED HUMAN S.S.B ANTIGEN TO DETECT ANTI‐SS.B ANTIBODIES R. Owe‐Young, S. Horn, J. Edmonds, A. SturgessPCR DETECTS CLONALITY IN PERIPHERAL BLOOD OF PATIENTS WITH MIXED CRYOGLOBULINAEMIA R. Kwiatek*l, A. Bennett, K. Trainor, M. Brisco, A. Morley and P. Roberts‐ThomsonA COMMON IDIOTYPE AND IMMUNOGLOBULIN GENE USAGE IN ANTI‐PHOSPHOLIPID ANTIBODIES. A. W. Hohmann, V. Boswanra, R. Comacchio, A. Neville and J. BradleyYTTRIUM SYNOVECTOMY: A META‐ANALYSIS OF THE LITERATURE G. JONES*SYNOVIAL FLUID CELLS, SYYOVIAL FLUID AND INTERLEUKIN‐4 ACTIVITY. P. H. Hart & M. J. AhernLENGTH OF STAY IN ACTIVE RHEUMATOID ARTHRITIS ‐ A PROSPECTIVE STUDY. G. Jones*, B. J. Smith, D. Mathers, G. A. C. Major, S. Ratnarajah, J. S. GlassDISCITIS: FIVE CASE PRESENTATIONS WITH DISCUSSION OF CLINICAL FEATURES AND INVESTIGATIVE FINDINGS. DA Kandiah*, DRE Barraclough, KD Muirden, HM Moran and G BuirskiTHE ROLE OF BONE SCINTIGRAPHY IN CHRONIC LOW BACK PAIN: COMPARISON OF SPECT AND PLANAR IMAGES AND ZYCAPOPHYSIAL JOINT INJECTION. A. C. Schwarzer*, A. M. Scott, S. Wang, R. Hoschl, J. C. Wiseman, R. A. Conner, D. Coote and R. LaurentTHE ROLE OF THE ZYGAPOPHYSIAL JOINT IN CHRONIC LOW BACK PAIN. A.C.Schwarzer*, S. Wann, R. Laurent, P. McNauaht and P. M. BrooksA MULTIDISCIPLINARY APPROACH TO THE MANAGEMENT OF CHRONIC PAIN EXPERIENCE AT THE NORTH SHORE PAIN CENTRE. A.C.Schwarzer*, C. Needs, R. Gardner, L. Tonkin, L. Baczocha and E. MornanTOTAL HIP ARTHROPLASTY IN THE YOUND ARTHRITIC PATIENT J.F. Bleasejl*, H. D. D. Tyer, J. R. York, J. KorberFACTOR VIII INHIBITORS IN RHEUMATOID ARTHRITIS J. F. Bleasel*, J. R. York, K. A. RickardJOINT REPLACEMENT IN PATIENTS WITH PAGETS DISEASE OF BONE S. Preston*, J. Hassall, J Korber, H. York, H. TyerDEPRESSED BONE MINERAL DENSITY IN ANKYLOSING SPONDYLITIS IS NOT ASSOCIATED WITH ALTERED MARKERS OF BONE TURNOVER. R. Will*, R. Palmer, R. Woodward, F. Ring, A. Calin and A. K. BhallaTHE PROBLEM OF OSTEOPOROSIS (OP) IN RHEUMATOID ARTHRITIS (RA). M.Marahani*, K.Chaudhuri, J.Heussler, T.Diamond, P. Butler and J. EdmondsA “FLEXICURVE” IS A PRECISE INSTRUMENT FOR OBTAINING REPRODUCIBLE MEASUREMENTS OF DORSAL, SPINAL CURVATURE IN ANKYLOSING SPONDYLITIS. R. Will*, P. Gaisford, B. Davey, J. Hall, R. Harrison, V. Papadoikos, H. Sewell, A. K. Bhalla and A. CalinPOSTMENOPAUSAL BONE LOSS IN RHEUMATOlD ARTHRITIS: EFFECT OF ESTROGENS AND ANDROGENS P. Samhrook*, J. Birmineharn, G. D. Champion, P. Kelly, S. Kempler, J. A. EismanRENAL FUNCTIONAL ABNORMALITIES IN ASSOCIATION WITH RHEUMATOID ARTHRITIS (RA). P. Savvas*, L.S. Ibels, A. Z. Gvory and P.M. BrooksSYDNEY SCLERODERMA EPIDEMIOLOGY STUDY 1974–1988. DECEASED DATA ‐ PRELIMINARY ANALYSIS. H Englert, *P Brooks, R PennyMETASTATIC CARCINOMATOUS ARTHRITIS. RADIOLOGICAL AND CYTOLOGICAL FINDINGS. A. Stockman*, S. K. Tang#, A. Khan+ and G. Buirski**INTERLEUKIN‐1β AND SOLUBLE INTERLEUKIN‐2 RECEPTOR LEVELS AS DISEASE ACTIVITY INDICATORS IN SCLERODERMA Mark Patrick, Bruce Kirkham, Meredith Graham, Leonard C. HarrisonSEVERE PRIMARY ERYTHROMELALGIA. A WARE CAUSE OF PAINFUL HANDS AND FEET IN CHILDHOOD. S. M. Randle*, H. Gold, P. Lawson and N. RobertsDETERMINANTS OF JOINT HYPERMOBILITY IN A YOUND ADULT POPULATION. L. M. March*, P. Brennan, A. J. SilmanLOWER POWER LASER THERAPY IN RA Heussler J K, Sturgess A DIS THERE A LINK BETWEEN B CELL DYSCRASIAS AND AUTOIMMUNITY? Hardiman K. L., Sturgess, A. DABNORMAL THERMOGRAPHIC PATTERNS OCCUR OVER THE SHOULDER AND UPPER LIMB IN ANKYLOSING SPONDYLITIS. R. Will, M. Burke, A. Tooke, D. Elvins, A. Calin and F. RingOUTCOME FOLLOWING LUMBOSACRAL ROOT DECOMPRESSION: A THERMOGRAPHIC ASSESSMENT. R. Will*, D. Elvins, S. Bulstrode, P. Bliss, G. Evison and F. RinaIS MCTD A DISTINCT RHEUMATIC DISEASE? Chen Shun‐le, Shen Nan, Yang Fu‐Tiang, Fan Li‐anSELECTIVE BRACHIAL PLEXUS INFUSION IN DIAGNOSIS AND TREATMENT OF REFRACTORY NECK AND ARM PAIN ‐ A PRELIMINARY REPORT A.‐L. Leslie, G.D. Champion, *M. McKell & M.L. CohenCORRELATION BETWEEN A SELF‐REPORTED QIJESlIONNAIRE AND OTHER MEASURES OF DISEASE ACTlVITY IN RHEUMATOID ARTHRITIS. K. Chaudhuri*, M. Marabani, J. Heussler, J. EdmondsSUBTYPES OF ANCA AND THEIR CLINICAL ASSOCIATIONS. M. N. Lassere*, S. Horn, A. D. SturgessAN ANIMAL MODEL OF METHOTREXATE HEPATOTOXICITY. M. J. Ahern, M. A. Jenner, D. Uzelin, P de la, M. HallDRAINAGE PROCEDURES IN SEPTIC ARTHRITIS ‐ A RETROSPECTIVE REVIEW. R. A. Kwiatek*, M. D. Smith, M. J. Ahern, P. J. Roberts‐ThomsonDOES STEROID PULSING INFLUENCE THE EFFICACY AND TOXICITY OF CHRYSOTHERAPY? A DOUBLE BLIND, PLACEBO CONTROLLED STUDY. M. D. Smith, M. J. Ahern and P. J. Roberts‐ThomsonPSYCHOLOGICAL EFFECTS OF PULSE METHYLPREDNISOLONE IN RHEUMATOID ARTHRITIS M. Bleakley, M. D. Smith, R. Kwiatek, P.J. Roberts‐Thomson, D. Cosh, M.J. AhernTHE PHARMACOKINETICS AND PHARMACODYNAMICS OF NAPPOXEN IN SYNOVIAL FLUID AND PLASMA. R. O. Day*, K. M. Williams, G. Geisslinger, and #H. Francis and #J. VialCASTANOSPERMINE AND ADJUVANT ARTHRITIS D. Mathers, K. Bowen, G. Major, D. Willenburg, C. Parish and W. CowdenEFFECT OF THALIDOMIDE ON POLYMORPHONUCLEAR LEUKOCYTE FUNCTION.* K. M. Williams, W Ye, F. Lohrer, J. Guille, R. O. Day, and #G. BlaschkeA REVIEW OF ALLOPURINOL DESENSITIZATION IN PATIENTS WITH GOVT, CHRONIC RENAL INSUFFICIENCY AND PREVIOUS ALLOPURINOL TOXICITY. T.M. Dawson*, P.F.J. Ryan and S. HallANALGESIC EFFICACY OF IBUPROFEN IN HUMAN EXPERIMENTAL PAIN. J. Walker, A Chandler, R. Sheather, and R DayMISOPROSTOL AUGMENTS THE ANTI‐INFLAMMATORY ACTIVITY OF NON‐STEROID, CORTICOSTEROID AND ANTOXIDANT DRUGS IN RATS. M.W. Whitehouse*, D. Haynes and B. Vernon‐RobertsHOW MANY PATIENTS SHOULD WE STUDY IN ANTI‐RHEUMATIC DRUG TRIALS? N. Bellamy*, G.A. Wells2 and J. Campbell1THE EFFECT OF SLOW ACTING ANTI‐RHEUMATIC DRUGS (SAARDS) AND COMBINATIONS OF SAARDS ON THE PRDUCTION OF CYTOKINES BY MONOCYTES. VA Danis*, Gradislava M. Franic and PM BrooksACYCLOVIR (ACV) IN RHEUMATOID ARTHRITIS (RA): A PILOT STUDY. W Harrison, A Cargeeg, P HanrahanCIRCULATING CYTOKINE LEVELS IN PATIENTS WITH RHEUMATOID ARTHRITIS: RESULTS OF A DOUBLE BLIND TRIAL WITH SULPHASALAZINE. VA Danis*, Gradislava M Franic, RM Lament and PM BrooksAN ASSESSMENT OF CARTILAGE DEGRADATION AND SYNTHESIS IN THE KNEE JOINT FOLLOWING INTRAARTICULAR TRIAMCINOLONE HEXACETONIDE. R. Will*, J Armas, J. BarnesAUROTHIOMALATE AND OTHER METAL IONS INHIBIT THE BINDING OF AP1 TRANSCRIPTION FACTOR TO ITS DNA RESPONSE ELEMENT. M.L. Handel*, C. K. W. Watts, R. O. Day and R. L. SutherlandTREATMENT WITH METHOTREXATE (MTX) REDUCES INTERLEUKIN‐1β (IL‐1β), KERATAN SULPHATE (KS) AND LEUKOCYTE CONCENTRATIONS IN RHEUMATOID SYNOVIAL FLUID (SF). G. J. Carroll R. Thomas, M. C. Bell, B. A. LaingCLEAVAGE OF CARTILAGE PROTEOGLYCANS BY STROMELYSINS AJ Fosano*, PJ Neame, TE Hardinaham, G MurphyMACROPHAGE FUNCTION IN GM‐CSF‐TRANSGENIC MICE. Michael J. Ellion*, Beverley Faulkner‐Jones and Donald MetcalfMIXED CONNECTIVE TISSUE DISEASE (MCTD): AN ELEVEN YEAR FOLLOW‐UP. M.N.Lassere*, L. Portek, A. D. Sturgess