Genetic Disorders Caused by Consanguineous Marriage in Radfan Districts – Yemen

Abstract Background Consanguineous marriage (≥ second cousins) is prevalent in Yemen (40–50%) and linked to increased genetic disorders. This study assesses its prevalence and health impacts in Radfan districts. Methodology A 2024 cross-sectional study of 1,065 randomly selected households. Data were collected via validated questionnaires supplemented by medical records where available. Analyses included consanguinity rates, inbreeding coefficients (F), sociocultural factors, and clinically validated genetic disorders. Statistical analysis employed χ² tests, multivariable logistic regression (adjusted ORs), and Cohen’s d for effect sizes. Results Consanguinity rate was 57.46%, higher in rural (37.09%) vs. urban areas (20.38%). University-educated wives had 71.9% lower consanguinity (adjusted OR = 0.28; 95% CI: 0.18–0.44). Adverse outcomes: abortion (26.67%), child mortality (adjusted OR = 3.1; 95% CI: 2.4–4.0), blood disorders (4.23%, 87% hemoglobinopathies), and disabilities (4.98%). Mean inbreeding coefficient F = 0.0625 (first-cousin equivalent). Conclusions High consanguinity directly increases genetic disorder burden. Urgent interventions: mandatory premarital screening for hemoglobinopathies, community-genetic literacy programs, and economic incentives for non-consanguineous marriages.