Formulation and Evaluation of Sulindac Nanosponge Loaded Gel for the Treatment of Arthritis

These are small, separate, and permeable matrix like structure known as NANOSPONGES. These can be used as topical, oral, inhalational delivery system. Its size is less than 1 µm. These are prepared using decomposable as well as water soluble polymeric material that allows maximum stability. Nanosponges, a promising class of nanomaterials, have garnered significant grown significantly due to their distinct and exceptional properties along with versatile applications in drug delivery. These nanostructures, characterized by their porous structure and significant surface areato-volume ratio, exhibit exceptional capability in encapsulating a broad spectrum of therapeutic agents, encompassing small molecules, proteins, and nucleic acids. This review article examines latest advancements seen on nanosponges’ research, with a focus on their synthesis methodologies, physicochemical properties, and mechanisms of drug loading and release. Furthermore, we highlight the promising therapeutic outcomes achieved through the utilization of nanosponges in various disease models, including cancer, infectious diseases, and neurological disorders. This article gives a brief about nanosponges with the introduction, merits, demerits, methodology, loading efficacy, assessment including aspects like particle size and zeta potential, SEM, entrapment effectiveness, study for release of drug along with summarizing with a mission to include it in future prospect in the field, emphasizing the need for further investigation to enlarged the perspective of full potential of nanosponge to be as innovative in delivery of drug to different platforms in clinical settings have been discussed