A New Cuproptosis-Related LncRNAs Prognostic Signature of Cervical Cancer

Abstract Cervical cancer (CC) is the most common gynecological tumor in the world. Cuproptosis is programmed cell death caused by increased intracellular concentrations of Cu2+. The aim of this study was to establish a new cuproptosis-related lncRNAs prognostic signature of cervical cancer to predict prognosis and guide treatment. Our study was the first to identify a cuproptosis-related lncRNAs in cervical cancer and established a cuproptosis-related lncRNAs prognostic signature. We also used qPCR to verify the relationship between these lncRNAs and cuproptosis in cervical cancer. This signature can be used to predict prognosis and response to immunotherapy in patients with cervical cancer. In addition, we found that there were differences in immune cell infiltration, immune function, and m6A between the high-risk and low-risk groups, and Patients in different risk groups have different sensitivities to small-molecule drug therapy. In addition, we build a nomogram model based on the risk model and clinical features, which is shown to have excellent predictive power. In summary, we have developed a novel prognostic cuproptosis-related lncRNAs signature that could provide new ideas for the treatment of cervical cancer patients.