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Expression of an Nkx3.1‐CRE gene using ROSA26 reporter mice
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AbstractThe genetic locus of Nkx3.1, an early murine marker of sclerotome and prostate development, was disrupted by a knock in of CRE recombinase via homologous recombination in embryonic stem cells. Cell fate mapping revealed previously unidentified cell lineages expanded from Nkx3.1‐expressing cell populations and recapitulated reported Nkx3.1 expression patterns. In lineage trace experiments of E18.5 Nkx3.1‐CRE; R26R embryos novel staining was observed in areas of the lungs, portions of the duodenum, and vertebral elements of the skeleton. β‐galactosidase activity measured in Nkx3.1‐CRE; R26R and Nkx3.2‐CRE; R26R embryos was observed in overlapping regions of the sclerotome but no apparent change in Nkx3.1 expression was seen in the Nkx3.2 mutants by in situ hybridization. genesis 44:550–555, 2006 Published 2006 Wiley‐Liss, Inc.
Title: Expression of an Nkx3.1‐CRE gene using ROSA26 reporter mice
Description:
AbstractThe genetic locus of Nkx3.
1, an early murine marker of sclerotome and prostate development, was disrupted by a knock in of CRE recombinase via homologous recombination in embryonic stem cells.
Cell fate mapping revealed previously unidentified cell lineages expanded from Nkx3.
1‐expressing cell populations and recapitulated reported Nkx3.
1 expression patterns.
In lineage trace experiments of E18.
5 Nkx3.
1‐CRE; R26R embryos novel staining was observed in areas of the lungs, portions of the duodenum, and vertebral elements of the skeleton.
β‐galactosidase activity measured in Nkx3.
1‐CRE; R26R and Nkx3.
2‐CRE; R26R embryos was observed in overlapping regions of the sclerotome but no apparent change in Nkx3.
1 expression was seen in the Nkx3.
2 mutants by in situ hybridization.
genesis 44:550–555, 2006 Published 2006 Wiley‐Liss, Inc.
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