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Fushi-Tarazu: Ftz
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Abstract
The homeodomain occurs between Ser-257 and Arg-316 (Laughon and Scott
1984). Like Antennapedia’s (Antp) homeodomain (ANTP-HD), the ftz homeodomain (FTZ-HD) has a Gln in position 9 of helix 3 (ftz Sequence, H3); this gives FTZ a binding specificity that distinguishes it from the bicoid ( b c d ) and paired (prd) products, in which Lys and Ser respectively occupy position 9 (Treisman et al. 1989). FTZ occurs as a family of phosphorylated isoforms; 19 differently charged forms were detected. Given the numerous Ser and Thr residues available for modification, the total number of specific isoforms could be much larger. Some isoforms are specific to certain embryonic stages (Krause and Gehring 1989).
Title: Fushi-Tarazu: Ftz
Description:
Abstract
The homeodomain occurs between Ser-257 and Arg-316 (Laughon and Scott
1984).
Like Antennapedia’s (Antp) homeodomain (ANTP-HD), the ftz homeodomain (FTZ-HD) has a Gln in position 9 of helix 3 (ftz Sequence, H3); this gives FTZ a binding specificity that distinguishes it from the bicoid ( b c d ) and paired (prd) products, in which Lys and Ser respectively occupy position 9 (Treisman et al.
1989).
FTZ occurs as a family of phosphorylated isoforms; 19 differently charged forms were detected.
Given the numerous Ser and Thr residues available for modification, the total number of specific isoforms could be much larger.
Some isoforms are specific to certain embryonic stages (Krause and Gehring 1989).
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