Uniqueness of Dr. JRK’s 777 oil and how rancidity distorts Wrightia tinctoria

<p class="abstract"><strong>Background:</strong> Several oil based AYUSH formulations are available for the treatment of psoriasis. In the recent time the importance given to <em>Wrightia tinctoria</em> has totally side-lined the quality of oil used in such preparation. Therefore, the importance of oil used in the formulation with reference to rancidity and how that would affect the therapeutic effect of <em>Wrightia tinctoria</em> needs to be studied.</p><p class="abstract"><strong>Methods:</strong> In the present study we have adopted the following methods such as acid value, DPPH assay, nitric oxide inhibition, anti-glycation, CAM assay and fibroblast toxicity. The base oil used was studied for the above then the oil that showed least acid value was incorporated with <em>Wrightia tinctoria</em> extract and then studied by the above methods.<strong></strong></p><p class="abstract"><strong>Results:</strong> The above study clearly show that the activity of <em>Wrightia tinctoria</em> decrease significantly when it was formulated in oil with high rancidity. Whereas the activity of <em>Wrightia tinctoria</em> was well preserved in oil with least rancidity. The contribution of acid value of oil in decreasing the activity of <em>Wrightia tinctoria</em> was much higher than the effect of acid value in increasing DPPH activity, Nitric oxide production, inducing glycation event and angiogenesis and causing fibroblast toxicity.</p><p><strong>Conclusions:</strong> The present study clearly concludes that the acid value of base oil would not only worsen psoriasis but also can inactivate and convert the herbal metabolites to toxic elements. Due diligence is necessary in preparing AYUSH drugs where not only the quality of herbs should be considered but also the oil base as well. </p>