Hyaluronic acid injection to coronary sulcus of the penis for the treatment of premature ejaculation

Abstract Hyaluronic acid (HA) injection has become a burgeoning method to treat premature ejaculation (PE). In this study, we proposed a modified technique: injecting hyaluronic acid around coronary sulcus to treat premature ejaculation with lowered complications. To improve the current injectable technique to decrease the complications of hyaluronic acid injection in penis while achieving similar effects. A total of 85 patients who had HA injection from January 2018 to December 2019 were analyzed retrospectively in our study. 31 patients received injection at glans penis and 54 patients received injection around coronary sulcus. Intravaginal ejaculation latency time (IELT) was mainly measured to estimate the efficacy and the severity of complications was assessed between two groups. The mean intravaginal ejaculation latency time increased from 123.0±37.28s to 483.5±123.4s at 1 month after intervention, and dropped to 332.7±78.50s and 278.8±67.67s at 3-month follow-up and 6-month follow-up, respectively. In the group of injecting at glans penis, the incidence of complications is 25.8%; it is 1.9% in the group of injecting around coronary sulcus. No severe complication was reported in both groups. modified technique of injecting around coronary sulcus decreases complications and it has the potential to become a new injectable technique for treating premature ejaculation.