Preparation and Characterization the Complexes of Dithiocarbamide Derived from Amino Acids and Evaluation of Their Biological Activity

This resaerch includes the preparation and characterization of a number of dithiocarbamate complexes of amino acids (tyrosine, and tryptophan) with a number of transitional elements Ni (II) and non-transitional elements Zn (II), Hg (II). The dithiocarbamate complexes were prepared directly in one container due to the difficulty of obtaining the ligands in a solid form. The complexes with the following general formulas were prepared: 1.Complexes with the formula [M(Tyrodtc)2], where M= Ni(II), Zn(II) ratio (metal: ligand) (2:1). 2. Complexes with the formula [M(Tryptodtc)2] where M= Zn(II), Hg(II) ratio (metal: ligand) (2:1). The structural formulas of the prepared complexes have been verified by some physical methods such as molar conductivity, magnetic sensitivity measurements, electronic spectra and infrared spectra. (1H, 13C) NMR. These measurements of the tetracoordinated complexes indicated that they take a square planar shape around the Ni(II) metal ion, and a tetrahedral shape around the Zn(II)], Hg(II) metal ions