Wurtz‐Fittig Reaction

Abstract The extension of Wurtz synthesis for the preparation of alkylated aromatic compounds by sodium‐mediated coupling of an alkyl and an aryl halide is generally referred to as the Wurtz–Fittig reaction. Analogously, the sodium‐mediated coupling between alkenyl halide and silyl halide to give alkenylsilane is termed as the Wurtz–Fittig silylation. The study finds that the Wurtz–Fittig reaction probably is not well suitable for the coupling between aryl halides, as evidenced by the incomplete coupling between phenyl sodium and chlorobenzene. In addition, it has been reported that 1,ω‐diaryl alkanes can easily be prepared by the Wurtz–Fittig reaction from 1,ω‐dihaloalkanes, even though such coupling is affected by a few factors. The original Wurtz–Fittig reaction is useful in organic synthesis.