THE ANTIDISBIOTIC EFFECT OF OIL CAKE FROM HIGH OLEIC SUNFLOWER SEEDS IN RATS WITH EXPERIMENTAL DYSBIOSIS

The work shows the relevance of the use in feeds production of means for correcting the microbiome. It is shown that the useof probiotic and prebiotic preparations increases the zootechnical efficiency of feed products, contributes to an increase in theamount of livestock and poultry products and forms its quality and safety. The expediency of using oil cake from high oleic sunflowerseeds in the production of feed products has been substantiated from the point of view of ensuring the nutritional value of productsand a positive effect on the norm of the flora of farm animals and poultry.Experimental dysbiosis in rats was reproduced with lincomycin. Oilcakes from linoleic and high oleic sunflower seeds wereadded to the diet in an amount of 10%. The experiment lasted 18 days. The activity of urease, lysozyme, elastase was determined inthe mucous membranes of the digestive tract (oral, small and large intestine), and the degree of dysbiosis was calculated.The therapeutic and prophylactic effect of oil cake from high oleic sunflower seeds on the development of inflammatory anddystrophic processes in the digestive system of rats under experimental dysbiosis was established. Studies have established an increasein the activity of elastase, urease, a decrease in the activity of lysozyme in rats with experimental dysbiosis. It was found thatthe consumption of high-oleic sunflower oil cake has a significantly greater therapeutic and prophylactic effect in comparison withthe linole-type sunflower oil cake, since it reduces the level of elastase by 23-45%, urease by 13.5-58% in the mucous membranes ofthe digestive tract. An increase of 25-94% in the activity of lysozyme in animals with experimental dysbiosis was established whenusing oil cake from high oleic sunflower. It was found that the consumption of oil cake from high oleic sunflower seeds reduces thedegree of dysbiosis in all tissues, especially in the small intestine (5 times).It was found that with dysbiosis in the digestive system, inflammatory-dystrophic processes develop as a result of a decreasein the level of nonspecific immunity. It was found that the consumption of oil cake from the seeds of high oleic sunflower has an antidisbioticeffect and, as a consequence, mucosoprotective effect.