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Possible Role of Osteopathic Manipulation Treatment in Alleviation of Finasteride-Induced Dementia through Modulation of HOMER-3 Gene Methylation
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Homer-3 gene is associated with neurological disorders that can affect
cognitive function, including dementia. It is a protein that regulates AMPAR
signaling in the hippocampus, which is involved in learning and memory.
Craniosacral therapy, an osteopathic manipulative treatment, causes a
reduction in symptoms associated with dementia and modulates the expression
of genes associated with dementia including the HOMER-3 gene. Finasteride is
a competitive inhibitor of 5-alpha-reductase (5-AR), an enzyme responsible
for the conversion of testosterone into dihydrotestosterone (DHT) and used
in the treatment of alopecia and prostatic enlargement. It induces atrophy
of the hippocampus and causes neuropsychiatric disorders including dementia.
In this work aimed at determining the methylation profile of finasteride on
Leydig cells, we cultured human Leydig cells in the presence of 0.5 μM
finasteride and performed whole-genome DNA methylation analysis using the
NimbleGen Human DNA Methylation 3x720K Promoter Plus CpG Island Array and
Ingenuity Pathway Analysis.Results showed that Finasteride induces
dysregulation of several genes associated with neuropsychiatric disorders
including the HOMER-3 gene implicated in dementia and modulated following
craniosacral osteopathic manipulation. We therefore propose investigation of
the effects of craniosacral osteopathic manipulative therapy on the
methylation profile of HOMER-3 gene and its possible role in alleviation of
neuropsychiatric symptoms linked to dementia following finasteride
treatment. The findings will reveal the potential use of osteopathic
manipulation therapy in treatment of finasteride-induced dementia through
epigenetic modulation of HOMER-3 gene and possible amelioration of atrophic
changes in hippocampus.
This abstract was presented at the American Physiology Summit 2025 and
is only available in HTML format. There is no downloadable file or PDF
version. The Physiology editorial board was not involved in the peer review
process.
Title: Possible Role of Osteopathic Manipulation Treatment in Alleviation of
Finasteride-Induced Dementia through Modulation of HOMER-3 Gene
Methylation
Description:
Homer-3 gene is associated with neurological disorders that can affect
cognitive function, including dementia.
It is a protein that regulates AMPAR
signaling in the hippocampus, which is involved in learning and memory.
Craniosacral therapy, an osteopathic manipulative treatment, causes a
reduction in symptoms associated with dementia and modulates the expression
of genes associated with dementia including the HOMER-3 gene.
Finasteride is
a competitive inhibitor of 5-alpha-reductase (5-AR), an enzyme responsible
for the conversion of testosterone into dihydrotestosterone (DHT) and used
in the treatment of alopecia and prostatic enlargement.
It induces atrophy
of the hippocampus and causes neuropsychiatric disorders including dementia.
In this work aimed at determining the methylation profile of finasteride on
Leydig cells, we cultured human Leydig cells in the presence of 0.
5 μM
finasteride and performed whole-genome DNA methylation analysis using the
NimbleGen Human DNA Methylation 3x720K Promoter Plus CpG Island Array and
Ingenuity Pathway Analysis.
Results showed that Finasteride induces
dysregulation of several genes associated with neuropsychiatric disorders
including the HOMER-3 gene implicated in dementia and modulated following
craniosacral osteopathic manipulation.
We therefore propose investigation of
the effects of craniosacral osteopathic manipulative therapy on the
methylation profile of HOMER-3 gene and its possible role in alleviation of
neuropsychiatric symptoms linked to dementia following finasteride
treatment.
The findings will reveal the potential use of osteopathic
manipulation therapy in treatment of finasteride-induced dementia through
epigenetic modulation of HOMER-3 gene and possible amelioration of atrophic
changes in hippocampus.
This abstract was presented at the American Physiology Summit 2025 and
is only available in HTML format.
There is no downloadable file or PDF
version.
The Physiology editorial board was not involved in the peer review
process.
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