Cardioprotective effect of camel milk against carbon tetrachloride induced toxicity

Camel milk a nutritional supplement has been known to have anti oxidant properties and has been used for more than a century for treatment of diseases. Twenty adult wistar rats weighing between 150g and 200g were used in the study to determine the protective effective of camel milk on carbon tetrachloride (CCl 4 ) induced cardio‐toxicity in rats. The rats were divided into 5 groups (A, B, C, D and E) of 4 animals each and were fed with rat feed and water for 30days. Control groups (A and B) were injected intraperitoneally (i/p) with 1ml/kgbw of paraffin oil on the 1st and 2nd days, and in addition group B was fed with camel milk for the remaining days. Groups C and D were injected i/p with CCl4 (1ml/kgbw) for 2 consecutive days and group D fed with camel milk for the remaining period. Group E were fed with camel milk and were injected i/p with CCl 4 on the last two days. Results showed a decrease in mean body weight of group C significant at p<0.05% while A and B; D and E showed increase in mean body weight. Macroscopically there was loss of normal pericardial outline in group C when compared with the normal. The Histomorphic appearance of cardiac cells in group C showed presence of inflammatory cells, scattered vacuoles and focal areas of necrosis with loss of intercalated disc. The control groups (A and B) and other experimental groups (D and E) appear normal with the preservation of the myocytes. This shows that camel milk is capable of protecting the heart against Carbon tetrachloride Induced toxicity and should be recommended for stress induced disorders. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .