The Efficacy of Arogyavardini Vati in Managing Sidhma Kushta with special reference to Plaque Psoriasis: A Comprehensive Review

Psoriasis is a chronic, relapsing inflammatory skin disorder affecting nearly 2% of the global population, of which plaque psoriasis is the most common form. Based on similarities in causative factors, pathogenesis, and clinical features, plaque psoriasis can be crosslinked with Sidhma Kushta, which is a Vata–Kapha Pradhana Kushta. The management of this condition is challenging due to its recurrent nature and the presence of comorbidities. Ayurveda offers several therapeutic formulations for the management of chronic skin disorders, among which Arogyavardini Vati, is a classical herbo-mineral preparation. It described in Rasaratna Samuchaya as Sarva Rogaprasamani, has been widely used by Ayurvedic practitioners. However, comprehensive scientific reviews evaluating its mode of action in Sidhma Kushta are limited. The present study critically reviews classical Ayurvedic literature along with contemporary scientific evidence to understand the therapeutic potential of Arogyavardini Vati in Sidhma Kushta, with special reference to plaque psoriasis. The formulation is predominantly Tikta, Katu, and Kashaya rasa along with Laghu–Ruksha Guna, which contribute to Agni Deepana, Tridosha Shamana, Kleda Shoshana, and Rakta Shodhana. Major ingredients exhibit anti-inflammatory, immunomodulatory, antioxidant, and keratinocyte-regulating actions through mechanisms including inhibition of the NF-κB pathway and modulation of pro-inflammatory cytokines. The review indicates that Arogyavardini Vati effectively addresses the underlying Samprapti of Sidhma Kushta and shows promising potential in the management of plaque psoriasis. Nevertheless, well-designed clinical trials are required to substantiate these findings and support wider clinical acceptance.