Evaluation of Toxicity, Antihyperglycemic and Hypoglycemic Activities of Mixtures of Extracts of 3 Varieties of Oyster Mushrooms

Our previous studies on the mushrooms showed that a mixture of three varieties of oyster mushrooms had better therapeutic properties than when the mushrooms were studied separately. To overcome the problem of diabetes, it was question here after studying the toxicity of mixtures of extracts (formulations) of 3 varieties of oyster mushrooms, to study the antihyperglycemic and hypoglycemic activity in the short term (over 2 hours of time) of these extracts. After formulating the mushrooms and obtaining the raw extracts, we proceeded to an acute toxicity of these extracts followed by the evaluation of antihyperglycemic and hypoglycemic tests on albino rats of the wistar type. In terms of results, we obtained 4 formulations namely F1, F2, F3 and F4. It appears in terms of toxicity that no signs of intoxication were observed. As for the antihyperglycemic test, 30min after ingestion of the extracts and glucose, all the groups of extracts exhibited had a lower blood glucose level than the positive control with the best extract best extract to limit the increase in postprandial blood glucose being the aqueous extract of formulation 3 (F3aq) with a slight increase in blood glucose of 0.3 g/l against an increase of 0.62g/l in the positive control. As for the hypoglycemic test, 120min after ingestion of glucose and extracts, the extracts showed a good ability to lower blood glucose compared to the positive control, the best extracts being the hydroethanolic extracts of formulations 1 and 3 (F1heth and F3heth) with respectively a decrease in blood glucose of 0.23g/l and 0.22g/l against 0.07g/l in the positive control. It can thus be concluded that formulated mushroom extracts do not show signs of toxicity and that the consumption of a mixture of oyster mushrooms could help in the fight against diabetes.