Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Coordinated Neutralization and Immune Activation by the Cytosolic Antibody Receptor TRIM21
View through CrossRef
ABSTRACT
TRIM21 is a high-affinity antibody receptor uniquely expressed in the cytosol of mammalian cells. Here we summarize its role in extending antibody protection into the intracellular environment and allowing nonprofessional cells to benefit from adaptive immunity. We highlight recent work that has shed light on how TRIM21 acts as both an immune sensor and effector. We also review how TRIM21 synergizes with other innate immune receptors to promote an integrated antiviral response.
Title: Coordinated Neutralization and Immune Activation by the Cytosolic Antibody Receptor TRIM21
Description:
ABSTRACT
TRIM21 is a high-affinity antibody receptor uniquely expressed in the cytosol of mammalian cells.
Here we summarize its role in extending antibody protection into the intracellular environment and allowing nonprofessional cells to benefit from adaptive immunity.
We highlight recent work that has shed light on how TRIM21 acts as both an immune sensor and effector.
We also review how TRIM21 synergizes with other innate immune receptors to promote an integrated antiviral response.
Related Results
CLINICAL SIGNIFICANCE OF ANTI-RO52/TRIM21 ANTIBODIES IN SYSTEMIC AUTOIMMUNE RHEUMATIC DISORDERS: PRELIMINARY RESULTS
CLINICAL SIGNIFICANCE OF ANTI-RO52/TRIM21 ANTIBODIES IN SYSTEMIC AUTOIMMUNE RHEUMATIC DISORDERS: PRELIMINARY RESULTS
Although antibodies targeting Ro52 protein/TRIM21 are commonly detected in systemic autoimmune rheumatic disorders (SARDs), their clinical significance and pathobiologic role remai...
Simultaneous Neutralization and Innate Immune Detection of a Replicating Virus by TRIM21
Simultaneous Neutralization and Innate Immune Detection of a Replicating Virus by TRIM21
ABSTRACT
Tripartite motif-containing 21 (TRIM21) is a cytosolic immunoglobulin receptor that mediates antibody-dependent intracellular neutralization (ADIN)....
Intracellular antibody activates innate immunity (P4135)
Intracellular antibody activates innate immunity (P4135)
Abstract
Immune responses are initiated by infection, yet pathogens evolve faster than the host receptors tasked with their detection. Antibodies can match pathogen ...
Intracellular detection of antibody-bound viruses and bacteria by TRIM21 (P4159)
Intracellular detection of antibody-bound viruses and bacteria by TRIM21 (P4159)
Abstract
Antibodies are a key component of the adaptive immune response but their activity has previously thought to be limited to the extracellular environment. We ...
EPD Electronic Pathogen Detection v1
EPD Electronic Pathogen Detection v1
Electronic pathogen detection (EPD) is a non - invasive, rapid, affordable, point- of- care test, for Covid 19 resulting from infection with SARS-CoV-2 virus. EPD scanning techno...
A basic model of calcium homeostasis in non-excitable cells
A basic model of calcium homeostasis in non-excitable cells
AbstractThe level of cytosolic calcium (Ca2+) in cells is tightly regulated to about 100 nM (pCa ≈ 7). Due to external stimuli, the basal cytosolic Ca2+level can temporarily be rai...
TWEAK Receptor Promotes Vascular Remodeling in Hypertension by Activating Autophagy
TWEAK Receptor Promotes Vascular Remodeling in Hypertension by Activating Autophagy
Background
Vascular remodeling, a pathological hallmark of hypertensive target‐organ damage, is critically modulated by autophagy. Given the emerging role of TW...
BIOASSAY OF ANTIGONADOTROPHIC SERA
BIOASSAY OF ANTIGONADOTROPHIC SERA
ABSTRACT
Data are presented on the reliability of the previously described bioassay of gonadotrophin neutralizing potency of antisera raised against HCG preparations. The s...