Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Electrochemical C3‐Site‐Selective Cyanation of Substituted Indoles
View through CrossRef
ABSTRACT
An electrochemical strategy for C3‐site selective cyanation of substituted indoles is reported. This protocol employs TMSCN as a cyano source, yielding C3‐cyano indoles in moderate to good yields. The electrochemical strategy is distinguished by its mild and oxidant‐free conditions, with good regioselectivity. A variety of protected and unprotected indoles has been successfully utilized in this methodology.
Title: Electrochemical C3‐Site‐Selective Cyanation of Substituted Indoles
Description:
ABSTRACT
An electrochemical strategy for C3‐site selective cyanation of substituted indoles is reported.
This protocol employs TMSCN as a cyano source, yielding C3‐cyano indoles in moderate to good yields.
The electrochemical strategy is distinguished by its mild and oxidant‐free conditions, with good regioselectivity.
A variety of protected and unprotected indoles has been successfully utilized in this methodology.
Related Results
Difluorocarbene-Based Cyanation of Aryl Iodides
Difluorocarbene-Based Cyanation of Aryl Iodides
A large number of efficient cyanation methods have been developed because of the wide range of applications of nitriles, but conventional methods usually suffer from the need for a...
Direct Catalytic Deaminative Cyanation of Aliphatic Primary Amines
Direct Catalytic Deaminative Cyanation of Aliphatic Primary Amines
The cyano group is an important and versatile functional group in medicinal chemistry. It is an important target in its own right while also serving as a precursor to other valuabl...
A Review on Thiocyanation of Indoles
A Review on Thiocyanation of Indoles
Background:
The thiocyanation of indoles is a direct way for carbon-sulfur bond formation to access
3-thiocyanato-indoles. 3-thiocyanato-indoles exhibit potent biological and pharm...
Book 2. POWER CONTROL FOR AN ELECTRICALLY POWERED WATER TREATMENT APPARATUS
Book 2. POWER CONTROL FOR AN ELECTRICALLY POWERED WATER TREATMENT APPARATUS
Detailed Description of How the Power Control of the Present Invention Synchronizes the Power Supply to a W2W Electrochemical Reactor The overall, general fundamental "patentable" ...
Regiospecific synthesis of 2,3-disubstituted indoles from isatins
Regiospecific synthesis of 2,3-disubstituted indoles from isatins
Indoles represent a structural element in a myriad of natural products and biologically active molecules. Of special importance are 2,3-disubstituted indoles. Thus, a number of met...
Indoles via Palladium‐Catalyzed Cyclization
Indoles via Palladium‐Catalyzed Cyclization
AbstractThe palladium‐catalyzed assembly of the functionalized pyrrole nucleus on a benzenoid scaffold is a widley used synthetic tool for the preparation of indole derivatives. Th...
Indoles as anticancer agents
Indoles as anticancer agents
<p>Indoles are natural products well known for their anticancer activity, which is related to their ability to induce cell death for many cancer cell lines. This review addre...
Impact of Microplastic on Roadside
Vegetable Cultivation: A Case Study
of Agricultural Farmland
Impact of Microplastic on Roadside
Vegetable Cultivation: A Case Study
of Agricultural Farmland
Microplastic (MPs) pollution poses a significant threat to environmental integrity, particularly in
agricultural areas adjacent to roads. There is a dire need to know the occurrenc...