May the Systemic Immune-Inflammation Index be an Indicator of Premature Ovarian Insufficiency?

Objective: This study aimed to determine whether there was a correlation between the systemic im-mune-inflammation index and ovarian reserve markers such as follicle stimulant hormone, estradiol, and anti-mullerian hormone Methods: The study comprised 65 people with premature ovarian insufficiency and 71 controls with sim-ilar demographics. The concentrations of hemoglobin, hematocrit, platelets, white blood cells, neutro-phils, and lymphocytes were evaluated. The neutrophil leukocyte ratio, platelet lymphocyte ratio, and systemic immune-inflammation index were calculated. The antral follicle count reserves of all patients were evaluated by transvaginal ultrasonography. An independent t-test was used for the comparison of the study and control groups. Correlations between variables were analyzed using Pearson's correlation test. A p value of 0.05 was considered significant. Results: The results of the neutrophil-to-lymphocyte ratio and the platelet-lymphocyte ratio showed a significant difference between the groups (p = 0.043). The Systemic Immune Inflammation Index value was the statistically significant difference found between the groups. There was a significant positive correlation between the systemic immune-inflammation index, neutrophil-to-lymphocyte ratio, platelet-lymphocyte ratio, and follicle stimulant hormone, while a significant negative correlation was found between the systemic immune-inflammation index, neutrophil-to-lymphocyte ratio, platelet-lymphocyte ratio, antral follicle count, and anti-mullerian hormone. In ROC analysis for SII at a cut-off level of 441.35, the sensitivity was 72.1% and the specificity was 68.9. Conclusion: Our study was the first in this field to reveal the relationship between premature ovarian failure and the systemic immune-inflammation index. According to our study results, the systemic im-mune-inflammation index, neutrophil-to-lymphocyte ratio, and platelet-lymphocyte ratio are significant-ly higher in individuals with ovarian failure.