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Improving the biocompatibility of parahydrogen hyperpolarized [1-13C]pyruvate
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ParaHydrogen Induced Polarization is a hyperpolarization method much less technically demanding and affordable than d-DNP. The Side Arm Hydrogenation method allowed to obtain hyperpolarized [1-13C]pyruvate that can be used for metabolic studies, but concerns about the safety and bio-compatibility of the final aqueous solution of the HP products may be present, due to organic solvents and metal complex. In this work, a method to remove all the traces of toxic solvents and metal complex from the final product will be presented, together with the 13C-MR images obtained using the metabolite thus hyperpolarized.
Title: Improving the biocompatibility of parahydrogen hyperpolarized [1-13C]pyruvate
Description:
ParaHydrogen Induced Polarization is a hyperpolarization method much less technically demanding and affordable than d-DNP.
The Side Arm Hydrogenation method allowed to obtain hyperpolarized [1-13C]pyruvate that can be used for metabolic studies, but concerns about the safety and bio-compatibility of the final aqueous solution of the HP products may be present, due to organic solvents and metal complex.
In this work, a method to remove all the traces of toxic solvents and metal complex from the final product will be presented, together with the 13C-MR images obtained using the metabolite thus hyperpolarized.
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