Antigenic characterization and clinical manifestations of feline Panleukopenia virus in Cats

<b>Objectives: </b>The study aimed to investigate the prevalence of feline panleukopenia virus among domestic and stray cats using a rapid antigen test and to determine its association with clinical signs, age, and sex. <b>Materials and Methods:</b> A total of 105 cats, both domestic and stray, were selected through purposive systematic random sampling. Screening for feline panleukopenia virus (FPV) was conducted using a commercial rapid antigen detection kit following the manufacturer’s instructions. Clinical signs, along with age and sex, were recorded and later analyzed for association with FPV positivity. <b>Results:</b> Domestic cats had a 31.42% prevalence rate, and stray cats had a 40% positive rate. Sexes were related to the positive rates, but the differences were not statistically significant (<i>p</i> > 0.05). The percentage of cats positive for panleukopenia was higher in diarrheic cats (51.42%) than in non-diarrheic cats (25.71%) (<i>p</i> < 0.05). Younger cats (< 1 year) showed a significantly higher infection rate (57.77%) than older cats (> 1 year) at 28.33% (<i>p</i> < 0.05). In terms of sex, 38.18% of females and 28% of males tested positive, and the difference was not statistically significant (<i>p</i> > 0.05). <b>Conclusion:</b> Feline Panleukopenia virus has a high prevalence in domestic and stray cats, and a strong association was found in the occurrence in cats having diarrhea and less than 1 year of age. Age is the most important risk, while sex and vomiting are not significantly associated with infection.