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Mesoblastic nephroma in adult
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Mesoblastic nephroma (MN) is an uncommon congenital tumor of infancy that rarely occurs in adults. We report a case of cellular MN in a 40-year-old woman. The tumor showed an unusual pattern of growth as an intracystic mass involving the adjacent renal parenchyma. Microscopically, it consisted of spindle cell proliferation with entrapped dilated renal tubules. Cartilaginous islands and numerous atypical mitotic figures were also noted. Spindle-shaped tumor cells show immunoreactivity for vimentin and variable positivity for estrogen and progesterone receptors (ER and PR). Epithelial membrane antigen was positive only in epithelial component. A combination of histological and immunohistochemical findings is useful in the differential diagnosis of cellular MN from other tumors of the kidney with spindle cell component.
Ovid Technologies (Wolters Kluwer Health)
Title: Mesoblastic nephroma in adult
Description:
Mesoblastic nephroma (MN) is an uncommon congenital tumor of infancy that rarely occurs in adults.
We report a case of cellular MN in a 40-year-old woman.
The tumor showed an unusual pattern of growth as an intracystic mass involving the adjacent renal parenchyma.
Microscopically, it consisted of spindle cell proliferation with entrapped dilated renal tubules.
Cartilaginous islands and numerous atypical mitotic figures were also noted.
Spindle-shaped tumor cells show immunoreactivity for vimentin and variable positivity for estrogen and progesterone receptors (ER and PR).
Epithelial membrane antigen was positive only in epithelial component.
A combination of histological and immunohistochemical findings is useful in the differential diagnosis of cellular MN from other tumors of the kidney with spindle cell component.
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