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Regioselective synthesis of 2-arylimidazo[2,1-a] isoquinolines
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Substituted phenacyl bromides react with isoquinoline to form the corresponding quaternary salts which, when heated in ammonium acetate and acetic acid in the presence of Cu(II)O, undergo regioselective cyclisation to give 2-arylimidazo[2,1-a]isoquinolines uniquely.
Title: Regioselective synthesis of 2-arylimidazo[2,1-a] isoquinolines
Description:
Substituted phenacyl bromides react with isoquinoline to form the corresponding quaternary salts which, when heated in ammonium acetate and acetic acid in the presence of Cu(II)O, undergo regioselective cyclisation to give 2-arylimidazo[2,1-a]isoquinolines uniquely.
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