APPLICATION OF PHOTOSENSITIZER-INCORPORATED INDIUM OXIDE NANOPARTICLES IN PHOTODYNAMIC THERAPY

Many disorders, both cancerous and non-cancerous, may be effectively treated using photodynamic therapy. In this scenario, photosensitizer drugs are first excited by light of the appropriate wavelength (in the visible-NIR range), after which they transmit their extra energy to molecular oxygen, resulting in the creation of strongly cytotoxic singlet oxygen. Indium oxide nanoparticles are optically transparent materials and can be used to incorporate fluorophores and photosensitizer drugs. Herein, we report the use of indium oxide nanoparticles incorporated with a photosensitizer. These nanoparticles have been synthesized in a methanolic medium. The characterization of prepared nanoparticles included FTIR, XRD, TEM, and optical studies (UV-visible and fluorescence spectroscopy). Cell viability studies demonstrated that the photosensitizer-incorporated nanoparticles showed cytotoxic effects only upon light irradiation. The results indicate the promise of photosensitizer-incorporated indium oxide nanoparticles as delivery agents in photodynamic therapy