Co-Relation between Plasma Beta2 Microglobulin Level and Cardiac Performance Factors in CKD Patients

Background: Cardiovascular disease mortality and morbidity is astonishingly high in CKD population. As renal function decreases beta2 microglobulin level starts to rise. There is an inverse relationship between e GFR and beta2 microglobulin level, but it is not established whether this protein causes cardiovascular dysfunction or not. This study was done to evaluate the relationship between plasma beta2 microglobulin level and cardiac performance in CKD patients. Objectives: To assess the beta2 microglobulin level in CKD and normal patients and to compare between them. To evaluate the relationship between beta2 microglobulin level and cardiac performance factors in CKD patients and to establish the relationship of beta2 microglobulin with eGFR. Materials and Methods: This case control study was done in DMCH from April 2017 to June 2018.86 patients were taken. Among them 46 patients were in case group and 40 patients were in control group. Case and control groups were labelled as group-I and group- II accordingly. Cases were taken from Nephrology outdoor and indoor unit of DMCH and also from cardiology outdoor unit. After selection of the patients informed consent was taken and blood send for beta2 microglobulin measurement in BSMMU, and Echo was done in DMCH cardiology department. For data analysis SPSS-24 was used. P value <o.o5 was and confidence interval at 95% was taken as significant. Result: Significant positive co-relation was found in between beta2 microglobulin level and CKD stages, thus negative co –relation with eGFR. Also beta2 microglobulin in group –I was 5.15±1.33 and in group –II it was 1.5±0.38 μgm/ml which was statistically significant. The cardiac performance factors like LVMI was found high in group –I(91.55±26.93) gm/m2and in group-II it was significantly low(77.4±21.7)gm/m2. The EF in group I was 62.96±4.03%, and in group –II it was 64.9±3.2%, which was also statistically significant. The other parameters like LVEDd and LVM was found ...